ArticleThe American journal of psychiatry2013
Microvascular abnormality in schizophrenia as shown by retinal imaging.
Article in The American journal of psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis.Schizophrenia bulletin · 2024Pooled it
- Retinal Changes in Schizophrenia: A Systematic Review and Meta-analysis Based on Individual Participant Data.Schizophrenia bulletin · 2020Pooled it
- Normobaric oxygen treatment for mild-to-moderate depression: a randomized, double-blind, proof-of-concept trial.Scientific reports · 2021Trial
- Advancing Brain and Body Vascular Imaging in Bipolar Disorder: A Report From the International Society for Bipolar Disorders Vascular Task Force.Bipolar disorders · 2026Review
- Evolution of Oculomics: From Naked Eye Observations to Artificial Intelligence over 100 Years.Ophthalmology science · 2026Article
- Compensatory hallucinogenesis across three neuropsychiatric disorders: a Bayesian account.Brain communications · 2026Review
- Retinal Vasculature in Schizophrenia Spectrum Disorder.Bioengineering (Basel, Switzerland) · 2025Article
- The association between preschoolers' retinal microcirculation and the indoor microbial environment: results of the ENVIRONAGE birth cohort.Scientific reports · 2025Article
- Association Between Optical Coherence Tomography Angiography (OCTA)-Based Retinal Vascular Densities and Empathy in Young Adults.Bioengineering (Basel, Switzerland) · 2025Article
- Abnormal arteriolar blood volume measured by 3D inflow-based vascular-space-occupancy (iVASO) MRI and resting-state BOLD fluctuations at 7 T in individuals with recent-onset schizophrenia.Psychoradiology · 2025Article
- Retinal layers and symptoms and inflammation in schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Oxygen and the Spark of Human Brain Evolution: Complex Interactions of Metabolism and Cortical Expansion across Development and Evolution.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Article
- Microstructural and Microvascular Alterations in Psychotic Spectrum Disorders: A Three-Compartment Intravoxel Incoherent Imaging and Free Water Model.Schizophrenia bulletin · 2023Article
- Childhood Social Isolation as a Predictor of Retinal Neuronal Thickness in Middle Age: A Lifecourse Birth Cohort Study.Psychosomatic medicine · 2023Article
- The Dunedin study after half a century: reflections on the past, and course for the future.Journal of the Royal Society of New Zealand · 2023Article
- Automated Systems for Calculating Arteriovenous Ratio in Retinographies: A Scoping Review.Diagnostics (Basel, Switzerland) · 2022Article
- Mapping Retinal Abnormalities in Psychosis: Meta-analytical Evidence for Focal Peripapillary and Macular Reductions.Schizophrenia bulletin · 2022Article
- Optical Coherence Tomography Angiography in Schizophrenia.Alpha psychiatry · 2022Article
- Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022Article
- Early-stage visual perception impairment in schizophrenia, bottom-up and back again.Schizophrenia (Heidelberg, Germany) · 2022Review
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveRetinal and cerebral microvessels are structurally and functionally homologous, but unlike cerebral microvessels, retinal microvessels can be noninvasively measured in vivo by retinal imaging. The authors tested the hypothesis that individuals with schizophrenia exhibit microvascular abnormality and evaluated the utility of retinal imaging as a tool for schizophrenia research.
methodParticipants were members of the Dunedin Study, a population-representative cohort followed from birth with 95% retention. Study members underwent retinal imaging at age 38. The authors assessed retinal arteriolar and venular caliber for all members of the cohort, including individuals who developed schizophrenia.
resultsStudy members who developed schizophrenia were distinguished by wider retinal venules, suggesting microvascular abnormality reflective of insufficient brain oxygen supply. Analyses that controlled for confounding health conditions suggested that wider retinal venules are not simply an artifact of co-occurring health problems in schizophrenia patients. Wider venules were also associated with a dimensional measure of adult psychosis symptoms and with psychosis symptoms reported in childhood.
conclusionsThe findings provide initial support for the hypothesis that individuals with schizophrenia show microvascular abnormality. Moreover, the results suggest that the same vascular mechanisms underlie subthreshold symptoms and clinical disorder and that these associations may begin early in life. These findings highlight the promise of retinal imaging as a tool for understanding the pathogenesis of schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.