ArticlePsychological research2014
Cognitive control and the COMT Val¹⁵⁸Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency.
Article in Psychological research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The Effect of Physical Activity and the Use of Active Video Games: Exergames in Children and Adolescents: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Improved human visuomotor performance and pupil constriction after choline supplementation in a placebo-controlled double-blind study.Scientific reports · 2015Trial
- Pro-cognitive effect of 1MeTIQ on recognition memory in the ketamine model of schizophrenia in rats: the behavioural and neurochemical effects.Psychopharmacology · 2020Article
- Dopamine: from prediction error to psychotherapy.Translational psychiatry · 2020Review
- Rumination impairs the control of stimulus-induced retrieval of irrelevant information, but not attention, control, or response selection in general.Psychological research · 2020Article
- Catechol-Frontiers in genetics · 2020Article
- Effect of the COMT Val158Met genotype on lateral prefrontal activations in young children.Developmental science · 2018Article
- COMT genotype is associated with plasticity in sense of body ownership: a pilot study.Psychological research · 2018Article
- The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults.Frontiers in aging neuroscience · 2018Article
- Video Games for Well-Being: A Systematic Review on the Application of Computer Games for Cognitive and Emotional Training in the Adult Population.Frontiers in psychology · 2018Article
- Exposing an "Intangible" Cognitive Skill among Collegiate Football Players: Enhanced Interference Control.Frontiers in psychology · 2018Article
- The Grand Challenge: Integrating Nomothetic and Ideographic Approaches to Human Cognition.Frontiers in psychology · 2017Article
- Technology consumption and cognitive control: Contrasting action video game experience with media multitasking.Attention, perception & psychophysics · 2016Article
- Music Makes the World Go Round: The Impact of Musical Training on Non-musical Cognitive Functions-A Review.Frontiers in psychology · 2015Review
- Article
- Eliminating the Attentional Blink through Binaural Beats: A Case for Tailored Cognitive Enhancement.Frontiers in psychiatry · 2015Article
- New directions in cognitive training: on methods, transfer, and application.Psychological research · 2014Article
- Association of COMT and COMT-DRD2 interaction with creative potential.Frontiers in human neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study investigated whether successful transfer of game-based cognitive improvements to untrained tasks might be modulated by preexisting neuro-developmental factors, such as genetic variability related to the catechol-O-methyltransferase (COMT)-an enzyme responsible for the degradation of dopamine. The COMT Val(158)Met genotype may differentially affect cognitive stability and flexibility, and we hypothesized that Val/Val homozygous individuals (who possess low prefrontal dopamine levels) show more pronounced cognitive flexibility than Met/-carriers (who possess high prefrontal dopamine levels). We trained participants, genotyped for the COMT Val(158)Met polymorphism on playing "Half-Life 2", a first-person shooter game which has been shown to improve cognitive flexibility. Pre-training (baseline) and post-training measures of cognitive flexibility were acquired by means of a task-switching paradigm. As expected, Val/Val homozygous individuals showed larger beneficial transfer effects than Met/-carriers. Our findings support the idea that genetic predisposition modulates transfer effects and that playing first-person shooter games promotes cognitive flexibility in individuals with a suitable genetic predisposition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.