ArticleNature communications2013
An experimental test on the probability of extinction of new genetic variants.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Selection Can Favor a Recombination Landscape That Limits Polygenic Adaptation.Molecular biology and evolution · 2025Article
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- Phenotypic stasis with genetic divergence.Peer community journal · 2023Article
- Selection on modifiers of genetic architecture under migration load.PLoS genetics · 2022Article
- Stochastic establishment of β-lactam-resistantProceedings. Biological sciences · 2022Article
- A single-nucleotide change underlies the genetic assimilation of a plastic trait.Science advances · 2021Article
- Antibiotic Breakdown by Susceptible Bacteria Enhances the Establishment of β-Lactam Resistant Mutants.Frontiers in microbiology · 2021Article
- Slower environmental change hinders adaptation from standing genetic variation.PLoS genetics · 2018Article
- Head-to-head comparison of three experimental methods of quantifying competitive fitness in C. elegans.PloS one · 2018Article
- Article
- Experimental Evolution withGenetics · 2017Review
- Evolving synergetic interactions.Journal of the Royal Society, Interface · 2016Article
- Adaptation to Temporally Fluctuating Environments by the Evolution of Maternal Effects.PLoS biology · 2016Article
- Reproductive assurance drives transitions to self-fertilization in experimental Caenorhabditis elegans.BMC biology · 2014Article
- The role of hermaphrodites in the experimental evolution of increased outcrossing rates in Caenorhabditis elegans.BMC evolutionary biology · 2014Article
- Genome evolution by matrix algorithms: cellular automata approach to population genetics.Genome biology and evolution · 2014Article
- Experimental determination of invasive fitness in Caenorhabditis elegans.Nature protocols · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost with high probability. Here we demonstrate that extinction rates decrease with increasing initial numbers of beneficial alleles, as expected, by performing invasion experiments with inbred lines of the nematode Caenorhabditis elegans. We further show that the extinction rates of deleterious alleles are higher than those of beneficial alleles, also as expected. Interestingly, we also find that for these inbred lines, when at intermediate frequencies, the fate of invaders might not result in their ultimate fixation or loss but on their maintenance. Our study confirms the key results from classical population genetics and highlights that the nature of adaptation can be complex.
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