Evidence map›Paper›PMID 24028937›Full record

ArticleGlobal health action2013

Factors associated with attrition, mortality, and loss to follow up after antiretroviral therapy initiation: data from an HIV cohort study in India.

Gerardo Alvarez-Uria, Praveen K Naik, Raghavakalyan Pakam, Manoranjan Midde

Registry-linked trialAbstract read
In one paragraph

Article in Global health action, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02454569 (Vicente Ferrer HIV Cohort Study), which is not on this map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02454569 recruitingnot on this map

Vicente Ferrer HIV Cohort Study

Typeobservational_patient_registrySponsorRural Development Trust HospitalRan2009 to 2040Enrolled30,000ConditionsHIV, Tuberculosis, Cryptococcosis, Opportunistic Infections
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  8. Retention of black and white participants in the selenium and vitamin E cancer prevention trial (SWOG-coordinated intergroup study S0000).Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerardo Alvarez-UriaDepartment of Infectious Diseases, Rural Development Trust Hospital, Bathalapalli, India; gerardouria@gmail.com.
Praveen K Naik
Raghavakalyan Pakam
Manoranjan Midde

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies from sub-Saharan Africa have shown high incidence of attrition due to mortality or loss to follow-up (LTFU) after initiating antiretroviral therapy (ART). India is the third largest country in the world in terms of HIV infected people, but predictors of attrition after ART initiation are not well known.

designWe describe factors associated with attrition, mortality, and LTFU in 3,159 HIV infected patients who initiated ART between 1 January 2007 and 4 November 2011 in an HIV cohort study in India. The study included 6,852 person-years with a mean follow-up of 2.17 years.

resultsAfter 5 years of follow-up, the estimated cumulative incidence of attrition was 37.7%. There was no significant difference between attrition due to mortality and attrition due to LTFU. Having CD4 counts <100 cells/µl and being homeless [adjusted hazard ratio (aHR) 3.1, 95% confidence interval (CI) 2.6-3.8] were associated with a higher risk of attrition, and female gender (aHR 0.64, 95% CI 0.6-0.8) was associated with a reduced risk of attrition. Living near a town (aHR 0.82, 95% CI 0.7-0.999) was associated with a reduced risk of mortality. Being single (aHR 1.6, 95% CI 1.2-2.3), illiteracy (aHR 1.3, 95% CI 1.1-1.6), and age <25 years (aHR 1.3, 95% CI 1-1.8) were associated with an increased risk of LTFU. Although the cumulative incidence of attrition in patients diagnosed with tuberculosis after ART initiation was 47.4%, patients who started anti-tuberculous treatment before ART had similar attrition to patients without tuberculosis (36 vs. 35.2%, P=0.19) after four years of follow-up.

conclusionsIn this cohort study, the attrition was similar to the one found in sub-Saharan Africa. Earlier initiation of ART, improving the diagnosis of tuberculosis before initiating ART, and giving more support to those patients at higher risk of attrition could potentially reduce the mortality and LTFU after ART initiation.

Indexed as

Lost to Follow-UpAdultAge FactorsAnti-HIV AgentsCD4 Lymphocyte CountCohort StudiesDrug MonitoringFemaleHIV InfectionsHumansIndiaMaleMiddle AgedPrevalenceProportional Hazards ModelsRisk FactorsAnti-HIV Agentsattritiondeveloping countrieshighly active antiretroviral therapylost to follow upmortalityrural health

Identifiers

PMID24028937
PMCPMC3773168

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.