Evidence map›Paper›PMID 24028801›Full record

Trial reportDrug and alcohol dependence2013

Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: a preliminary study.

Xingbao Li, Robert J Malcolm, Kristina Huebner, Colleen A Hanlon, Joseph J Taylor, Kathleen T Brady, Mark S George, Ronald E See

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  18. A Scoping Review on Cue Reactivity in Methamphetamine Use Disorder.International journal of environmental research and public health · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xingbao LiMedical University of South Carolina, United States. Electronic address: lixi@musc.edu.
Robert J Malcolm
Kristina Huebner
Colleen A Hanlon
Joseph J Taylor
Kathleen T Brady
Mark S George
Ronald E See
Medical University of South Carolina · USRalph H. Johnson VA Medical Center · US

Funding

Translational Research in Addiction CenterP20DA022658 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SEE, RONALD E · 2006 to 2009
$3.0M
Cortical Inhibition and Corpus Callosum Integrity in Cocaine UsersK01DA027756 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HANLON, COLLEEN A · 2010 to 2014
$801k
NIDA NIH HHS K01 DA027756NIDA NIH HHS P20 DA022658
6 · The paper itself

Abstract

backgroundRepetitive transcranial magnetic stimulation (rTMS) can temporarily interrupt or facilitate activity in a focal brain region. Several lines of evidence suggest that rTMS of the dorsolateral prefrontal cortex (DLPFC) can affect processes involved in drug addiction. We hypothesized that a single session of low-frequency rTMS of the left DLPFC would modulate cue-induced craving for methamphetamine (MA) when compared to a sham rTMS session.

methodsIn this single-blind, sham-controlled crossover study, 10 non-treatment seeking MA-dependent users and 8 healthy controls were randomized to receive 15 min of sham and real (1 Hz) DLPFC rTMS in two experimental sessions separated by 1h. During each rTMS session, participants were exposed to blocks of neutral cues and MA-associated cues. Participants rated their craving after each cue block.

resultsIn MA users, real rTMS over the left DLPFC increased self-reported craving as compared to sham stimulation (17.86 ± 1.46 vs. 24.85 ± 1.57, p=0.001). rTMS had no effect on craving in healthy controls. One Hertz rTMS of the left DLPFC was safe and tolerable for all participants.

conclusionsLow frequency rTMS of the left DLPFC transiently increased cue-induced craving in MA participants. These preliminary results suggest that 1 Hz rTMS of the left DLPFC may increase craving by inhibiting the prefrontal cortex or indirectly activating subcortical regions involved in craving.

Indexed as

Central Nervous System StimulantsCuesMethamphetamineAdultAmphetamine-Related DisordersDiagnostic and Statistical Manual of Mental DisordersFemaleFunctional LateralityHumansMaleMovementPhotic StimulationPrefrontal CortexReproducibility of ResultsSeizuresSingle-Blind MethodCentral Nervous System StimulantsMethamphetamineCravingDorsolateral prefrontal cortexMethamphetamineTranscranial magnetic stimulation

Identifiers

PMID24028801
PMCPMC4196687
OpenAlexW2069411649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.