ArticleClinical and experimental immunology2013
Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization.
Article in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Regulation of Intestinal Inflammation by Dietary Fats.Frontiers in immunology · 2020Pooled it
- Oxidized low-density lipoprotein increased susceptibility to primary nephrotic syndrome by regulating the Treg/Th17 ratio via MEG3 signalling.Archives of medical science : AMS · 2026Article
- Electroacupuncture Reduces Inflammatory Bowel Disease in Obese Mice by Activating the Nrf2/HO-1 Signaling Pathways and Repairing the Intestinal Barrier.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Effect of Clostridium butyricum on High-Fat Diet-Induced Intestinal Inflammation and Production of Short-Chain Fatty Acids.Digestive diseases and sciences · 2023Article
- The Effects of a High-Fat Diet on Inflammatory Bowel Disease.Biomolecules · 2023Review
- Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota-A Narrative Review.Nutrients · 2022Review
- Impending Mental Health Issues During Coronavirus Disease 2019 - Time for Personalized Nutrition Based on the Gut Microbiota to Tide Over the Crisis?Frontiers in neuroscience · 2021Article
- Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Cytomegalovirus Infection Exacerbates Experimental Colitis by Promoting IL-23 Production.Inflammation · 2020Article
- Harnessing Gut Microbes for Mental Health: Getting From Here to There.Biological psychiatry · 2018Review
- Inflammatory Links Between High Fat Diets and Diseases.Frontiers in immunology · 2018Review
- Reactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis.Frontiers in immunology · 2018Article
- Microbial Changes and Host Response in F344 Rat Colon Depending on Sex and Age Following a High-Fat Diet.Frontiers in microbiology · 2018Article
- The Microbiome: A New Target for Research and Treatment of Schizophrenia and its Resistant Presentations? A Systematic Literature Search and Review.Frontiers in pharmacology · 2018Article
- High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22.Scientific reports · 2016Article
- Nutritional concerns in pediatric inflammatory bowel disease.Korean journal of pediatrics · 2016Review
- Article
- Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity.The Journal of clinical investigation · 2015Review
- The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications.Journal of gastroenterology · 2014Review
- Role of "Western diet" in inflammatory autoimmune diseases.Current allergy and asthma reports · 2014Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous reports have shown that a diet containing large amounts of trans fatty acids (TFAs) is a major risk factor for metabolic disorders. Although recent studies have shown that TFAs promote intestinal inflammation, the underlying mechanisms are unknown. In this study, we examined the effects of dietary fat containing TFAs on dextran sodium sulphate (DSS)-induced colitis. C57 BL/6 mice were fed a diet containing 1·3% TFAs (mainly C16:1, C18:1, C18:2, C20:1, C20:2 and C22:1), and then colitis was induced with 1·5% DSS. Colonic damage was assessed, and the mRNA levels of proinflammatory cytokines and major regulators of T cell differentiation were measured. The TFA diet reduced survival and exacerbated histological damage in mice administered DSS compared with those fed a TFA-free diet. The TFA diet significantly elevated interleukin (IL)-6, IL-12p40, IL-23p19 and retinoic acid-related orphan receptor (ROR)γt mRNA levels in the colons of DSS-treated animals. Moreover, IL-17A mRNA levels were elevated significantly by the TFA diet, with or without DSS treatment. We also examined the expression of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and peritoneal macrophages. These cells were exposed to TFAs (linoelaidic acid or elaidic acid) with or without LPS and the mRNA levels of various cytokines were measured. IL-23p19 mRNA levels were increased significantly by TFAs in the absence of LPS. Cytokine expression was also higher in LPS-stimulated cells exposed to TFAs than in unexposed LPS-stimulated cells. Collectively, our results suggest that TFAs exacerbate colonic inflammation by promoting Th17 polarization and by up-regulating the expression of proinflammatory cytokines in the inflamed colonic mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.