ArticleInternational wound journal2015
Vessel transformation in chronic wounds under topical negative pressure therapy: an immunohistochemical analysis.
Article in International wound journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Graphene Far-Infrared Therapy Enhances Diabetic Wound Healing Through Potential Mitigation of Oxidative Stress and Inflammation and Regulation of Chemokines and Macrophage Polarization.International journal of molecular sciences · 2026Article
- Negative-Pressure Wound Therapy: What We Know and What We Need to Know.Advances in experimental medicine and biology · 2023Article
- An improved bone transport surgical method for treating chronic ischemic ulcers (thromboangiitis obliterans).Frontiers in surgery · 2022Article
- Novel imaging methods reveal positive impact of topical negative pressure application on tissue perfusion in an in vivo skin model.International wound journal · 2021Article
- Role of Endoscopic Vacuum Therapy as a Treatment for Anastomosis Leak after Esophageal Cancer Surgery.The Korean journal of thoracic and cardiovascular surgery · 2020Article
- Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects.World journal of gastrointestinal endoscopy · 2019Review
- A New Procedure for Wrapped-Negative Pressure Wound Therapy for Congestion After Arterialized Venous Flap Surgery.Clinical medicine insights. Case reports · 2017Article
- Tadalafil therapy and severe chronic foot wound resolution.International wound journal · 2015Article
- PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat.BMC biotechnology · 2014Article
- Endoscopic Vacuum Therapy: When and How to Use It?GE Portuguese journal of gastroenterologyReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The underlying physiological mechanism of topical negative pressure (TNP) therapy is not yet completely understood. This prospective clinical study aims to clarify a potential influence of TNP therapy on vessel proliferation and hypoxia in chronic wounds. TNP was applied on chronic wounds of 16 patients (-125 mmHg) to prepare them for a plastic-surgical reconstruction using free or pedicled flaps. Tissue biopsies were taken from the wound edge and wound bed at different time points. All samples were stained with haematoxylin and eosin, hypoxia-induced factor-1α and endothelial cell markers (CD31 and CD34) for the immunohistological analysis of inflammation, hypoxia and vessel proliferation. Between day 5 and day 8 of treatment, a considerable increase in blood vessel density could be observed, reaching a maximum of approximately 200% in contrast to the vessel density prior to treatment. In addition, the number of hypoxic and inflammatory cells was found to be increased at particular time points. This study demonstrates a stimulating effect on vessel proliferation under TNP treatment. TNP appears to support (neo-) angiogenesis and transformation of chronic non-healing wounds in a physiological wound healing process when combined with surgical debridement. This effect underlines the positive influence of TNP in the treatment of chronic wounds as shown by various clinical reports.
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