ArticleNeuropathology and applied neurobiology2014
A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia.
Article in Neuropathology and applied neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Opposing interictal dynamics in Alzheimer's disease and epilepsy.Progress in neurobiology · 2026Article
- Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures.Nature chemical biology · 2025Article
- Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development.Scientific reports · 2025Article
- Focal granule cell bilamination of the dentate gyrus-its prevalence across the human age spectrum and review of the literature.Journal of neuropathology and experimental neurology · 2025Review
- Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy.Journal of translational medicine · 2023Article
- Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination.Frontiers in neurology · 2023Article
- Mechanisms Involved in Epileptogenesis in Alzheimer's Disease and Their Therapeutic Implications.International journal of molecular sciences · 2022Review
- Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population.Brain pathology (Zurich, Switzerland) · 2018Article
- Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes.Frontiers in neuroanatomy · 2018Review
- Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.Annals of clinical and translational neurology · 2015Article
- Comorbidities in Neurology: Is adenosine the common link?Neuropharmacology · 2015Review
- Review: Hippocampal sclerosis in epilepsy: a neuropathology review.Neuropathology and applied neurobiology · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimsHippocampal sclerosis (HS) is long-recognized in association with epilepsy (HSE ) and more recently in the context of cognitive decline or dementia in the elderly (HSD ), in some cases as a component of neurodegenerative diseases, including Alzheimer's disease (AD) and fronto-temporal lobe dementia (FTLD). There is an increased risk of seizures in AD and spontaneous epileptiform discharges in the dentate gyrus of transgenic AD models; epilepsy can be associated with an age-accelerated increase in AD-type pathology and cognitive decline. The convergence between these disease processes could be related to hippocampal pathology. HSE typically shows re-organization of both excitatory and inhibitory neuronal networks in the dentate gyrus, and is considered to be relevant to hippocampal excitability. We sought to compare the pathology of HSE and HSD , focusing on re-organization in the dentate gyrus.
methodsIn nine post mortem cases with HSE and bilateral damage, 18 HSD and 11 controls we carried out immunostaining for mossy fibres (dynorphin), and interneuronal networks (NPY, calbindin and calretinin) on sections from the mid-hippocampal body. Fibre sprouting (FS) or loss of expression in the dentate gyrus was semi-quantitatively graded from grade 0 (normal) to grade 3 (marked alteration).
resultsSignificantly more re-organization was seen with all four markers in the HSE than HSD group (P < 0.01). Mild alterations were noted in HSD group with dynorphin (FS in 3 cases), calretinin (FS in 6 cases), NPY (FS in 11 cases) and calbindin (loss in 10 cases). In eight HSD cases, alteration was seen with more than one antibody but in no cases were the highest grades seen. We also noted NPY and, to a lesser extent, calretinin labelling of Hirano bodies in CA1 of AD cases and some older controls, but not in HSE .
conclusionReorganization of excitatory and inhibitory networks in the dentate gyrus is more typical of HSE . Subtle alterations in HSD may be a result of increased hippocampal excitability, including unrecognized seizure activity. An unexpected finding was the identification of NPY-positive Hirano bodies in HSD but not HSE , which may be a consequence of the relative vulnerabilities of interneurons in these conditions.
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