ArticleJournal of the American Geriatrics Society2013
Midlife hypertensive status and cognitive function 20 years later: the Southall and Brent revisited study.
Article in Journal of the American Geriatrics Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2015Pooled it
- Midlife hypertension and late-life cognition: weighting the LifeAfter90 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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- Article
- Dissecting the vascular-cognitive nexus: energetic vs. conventional hemodynamic parameters.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Associations of carotid atherosclerosis with cognitive function and brain health: Findings from a UK tri-ethnic cohort study (Southall and Brent Revisited).Atherosclerosis plus · 2024Article
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly.Therapeutic advances in chronic disease · 2022Review
- Association between blood pressure control status, visit-to-visit blood pressure variability, and cognitive function in elderly Chinese: A nationwide study.Frontiers in public health · 2022Article
- Different hypertension thresholds and cognitive decline: a pooled analysis of three ageing cohorts.BMC medicine · 2021Article
- Effects of Blood Pressure on Cognitive Performance in Aging: A Systematic Review.Brain sciences · 2020Review
- Association of blood pressure with cognitive function at midlife: a Mendelian randomization study.BMC medical genomics · 2020Article
- Future Directions for Dementia Risk Reduction and Prevention Research: An International Research Network on Dementia Prevention Consensus.Journal of Alzheimer's disease : JAD · 2020Article
- Differential Associations of Diastolic and Systolic Pressures With Cerebral Measures in Older Individuals With Mild Cognitive Impairment.American journal of hypertension · 2018Article
- Long-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study.Journal of the American Heart Association · 2018Article
- In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018Article
- Isometric Handgrip as an Adjunct for Blood Pressure Control: a Primer for Clinicians.Current hypertension reports · 2017Review
- Blood Pressure and All-Cause Mortality by Level of Cognitive Function in the Elderly: Results From a Population-Based Study in Rural Greece.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2016Review
- Increased attrition of leukocyte telomere length in young adults is associated with poorer cognitive function in midlife.European journal of epidemiology · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesTo investigate long-term prospective associations between a range of measurements of hypertensive status in midlife and cognitive impairment 20 years later.
designCohort study.
settingTwo areas (Southall and Brent) of northwest London.
participantsSurvey samples of a multiethnic population (European, African Caribbean, South Asian) aged 40 to 67 were followed up 20 years later. MEASUREMENTS: Comprehensive cardiovascular assessments were performed at baseline, including measurements of resting blood pressure (BP) and, in a subsample, ambulatory BP. At follow-up, a battery of cognitive assessments was administered, and a composite outcome was derived, with impairment defined as the lowest 10% within each ethnic group. Logistic regression models were used to investigate associations with prior measures of hypertensive status.
resultsIn 1,484 participants at follow-up, cognitive impairment showed significant U-shaped associations with baseline diastolic BP (DBP) and mean arterial pressure (MAP; strongest for those aged ≥ 50 at baseline), independent of a range of covariates, but no associations were found with systolic BP or pulse pressure. Cognitive impairment was also associated with antihypertensive medication use and higher evening ambulatory DBP at baseline. No substantial differences in strengths of association were found between ethnic groups.
conclusionLow and high DBP and MAP were associated with cognitive impairment 20 years later. Higher evening DBP on ambulatory monitoring was also associated with greater risk.
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