ArticleBioMed research international2013
Inflammatory bowel disease therapies and gut function in a colitis mouse model.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Mechanisms of Action of Exclusive Enteral Nutrition and Other Nutritional Therapies in Crohn's Disease.Nutrients · 2024Review
- Review
- A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease.Molecules (Basel, Switzerland) · 2024Article
- Intestinal Microbiome in Dogs with Chronic Hepatobiliary Disease: Can We Talk about the Gut-Liver Axis?Animals : an open access journal from MDPI · 2023Article
- The Effect of Formula-based Nutritional Treatment on Colitis in a Murine Model.Journal of Korean medical science · 2021Article
- Nutritional Therapy Strategies in Pediatric Crohn's Disease.Nutrients · 2021Review
- Exclusive Enteral Nutrition in Adult Crohn's Disease: an Overview of Clinical Practice and Perceived Barriers.Clinical and experimental gastroenterology · 2021Review
- Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis.Cellular and molecular gastroenterology and hepatology · 2021Article
- Importance of nutritional therapy in the management of intestinal diseases: beyond energy and nutrient supply.Intestinal research · 2019Article
- Review
- Article
- Acute Colitis Caused by Helicobacter trogontum in Immunocompetent Patient.Emerging infectious diseases · 2016Article
- The major pathway by which polymeric formula reduces inflammation in intestinal epithelial cells: a microarray-based analysis.Genes & nutrition · 2015Article
- Exclusive enteral nutrition in children with Crohn's disease.World journal of gastroenterology · 2015Review
- DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells.Scientific reports · 2015Article
- Effect of exclusive enteral nutrition on the microbiota of children with newly diagnosed Crohn's disease.Clinical and translational gastroenterology · 2015Article
- Insights into the Role of Erysipelotrichaceae in the Human Host.Frontiers in cellular and infection microbiology · 2015Article
- Microbiome associations of therapeutic enteral nutrition.Nutrients · 2014Review
- Paediatric inflammatory bowel disease: a mechanistic approach to investigate exclusive enteral nutrition treatment.Scientifica · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExclusive enteral nutrition (EEN) is a well-established approach to the management of Crohn's disease. Aim. To determine effects of EEN upon inflammation and gut barrier function in a colitis mouse model.
methodsInterleukin-10-deficient mice (IL-10(-/-)) were inoculated with Helicobacter trogontum and then treated with EEN, metronidazole, hydrocortisone, or EEN and metronidazole combination. Blood and tissue were collected at 2 and 4 weeks with histology, mucosal integrity, tight junction integrity, inflammation, and H. trogontum load evaluated.
resultsH. trogontum induced colitis in IL-10(-/-) mice with histological changes in the cecum and colon. Elevated mucosal IL-8 mRNA in infected mice was associated with intestinal barrier dysfunction indicated by decreased transepithelial electrical resistance and mRNA of tight junction proteins and increased short-circuit current, myosin light chain kinase mRNA, paracellular permeability, and tumor necrosis factor- α and myeloperoxidase plasma levels (P < 0.01 for all comparisons). EEN and metronidazole, but not hydrocortisone, treatments restored barrier function, maintained gut barrier integrity, and reversed inflammatory changes along with reduction of H. trogontum load (versus infected controls P < 0.05).
conclusionH. trogontum infection in IL-10(-/-) mice induced typhlocolitis with intestinal barrier dysfunction. EEN and metronidazole, but not hydrocortisone, modulate barrier dysfunction and reversal of inflammatory changes.
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