ArticleCase reports in emergency medicine2013
Acute liver failure associated with levetiracetam and lacosamide combination treatment for unspecified epileptic disorder.
Article in Case reports in emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Vanishing bile duct syndrome: a sequela of temozolomide and levetiracetam-induced cholestatic liver injury.BMJ case reports · 2024Article
- Evaluating the bioequivalence of levetiracetam brand and generic oral tablets available in the Saudi market in vivo.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Severe drug-induced liver injury caused by levetiracetam - A case report and review of the literature.Epilepsy & behavior reports · 2021Article
- Decompensated Liver Disease in a Patient with Neurocysticercosis.Digestive diseases and sciences · 2017Review
- Levetiracetam associated acute hepatic failure requiring liver transplantation: case report.Journal of neurology · 2016Article
- Lacosamide as add-on treatment of focal symptomatic epilepsy in a patient with alcoholic liver cirrhosis.Epilepsy & behavior case reports · 2014Article
- A Rare Case of Drug-Induced Liver Injury Caused by Levetiracetam.Asian journal of neurosurgeryArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim. Levetiracetam is a second-generation antiepileptic drug. It is approved as an adjunctive treatment of partial onset seizures with or without secondary generalization. It is considered safe with less than 1% of patients with transient elevations of liver enzymes. Methods. We report a case of acute liver failure secondary to Levetiracetam in combination with Lacosamide documented with a liver biopsy. Results. Liver biopsy demonstrated acute liver injury with a predominant submassive necrosis pattern and features of a drug-induced hepatitis. Conclusions. This is the first published case of acute liver failure due to antiepileptic therapy with Levetiracetam in combination with Lacosamide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.