ReviewFrontiers in behavioral neuroscience2013
DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders.
Review in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review.Translational psychiatry · 2017Pooled it
- BMAL1-Potential Player of Aberrant Stress Response in Q31L Mice Model of Affective Disorders: Pilot Results.International journal of molecular sciences · 2024Article
- Behavioral analysis through the lifespan ofiScience · 2023Article
- A protocol for establishing a male G×E schizophrenia mouse model.STAR protocols · 2022Article
- Zebrafish as a model to investigate the CRH axis and interactions with DISC1.Current opinion in endocrine and metabolic research · 2022Review
- Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combiningiScience · 2022Article
- Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal-Hippocampal Coupling and the Cognitive Performance Throughout Development.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Interplay of Prenatal and Postnatal Risk Factors in the Behavioral and Histological Features of a "Two-Hit" Non-Genetic Mouse Model of Schizophrenia.International journal of molecular sciences · 2020Article
- Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics.Scientific reports · 2020Article
- Disrupted-in-Schizophrenia 1 (DISC1) Overexpression and Juvenile Immune Activation Cause Sex-Specific Schizophrenia-Related Psychopathology in Rats.Frontiers in psychiatry · 2019Article
- PSD95: A synaptic protein implicated in schizophrenia or autism?Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Adolescent Isolation Interacts WithFrontiers in cellular neuroscience · 2018Article
- Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function.Human molecular genetics · 2017Article
- From Shortage to Surge: A Developmental Switch in Hippocampal-Prefrontal Coupling in a Gene-Environment Model of Neuropsychiatric Disorders.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Utility and validity of DISC1 mouse models in biological psychiatry.Neuroscience · 2016Review
- Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.Progress in neurobiology · 2016Review
- Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis.Biological psychiatry · 2015Review
- Schizophrenia as a disorder of molecular pathways.Biological psychiatry · 2015Review
- Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels.Biological psychiatry · 2014Article
Corrections and comments
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2 authors at 1 institution in 1 country.
Funding
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Abstract
DISC1 was discovered in a Scottish pedigree in which a chromosomal translocation that breaks this gene segregates with psychiatric disorders, mainly depression and schizophrenia. Linkage and association studies in diverse populations support DISC1 as a susceptibility gene to a variety of neuropsychiatric disorders. Many Disc1 mouse models have been generated to study its neuronal functions. These mouse models display variable phenotypes, some of them relevant to schizophrenia, others to depression. The Disc1 mouse models are popular genetic models for studying gene-environment interactions in schizophrenia. Five different Disc1 models have been combined with environmental factors. The environmental stressors employed can be classified as either early immune activation or later social paradigms. These studies cover major time points along the neurodevelopmental trajectory: prenatal, early postnatal, adolescence, and adulthood. Various combinations of molecular, anatomical and behavioral methods have been used to assess the outcomes. Additionally, three of the studies sought to rescue the resulting abnormalities. Here we provide background on the environmental paradigms used, summarize the results of these studies combining Disc1 mouse models with environmental stressors and discuss what we can learn and how to proceed. A major question is how the genetic and environmental factors determine which psychiatric disorder will be clinically manifested. To address this we can take advantage of the many Disc1 models available and expose them to the same environmental stressor. The complementary experiment would be to expose the same model to different environmental stressors. DISC1 is an ideal gene for this approach, since in the Scottish pedigree the same chromosomal translocation results in different psychiatric conditions.
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