ArticleFrontiers in systems neuroscience2013
Different correlation patterns of cholinergic and GABAergic interneurons with striatal projection neurons.
Article in Frontiers in systems neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Striatal function scrutinized through the PAN-TAN-FSI triumvirate.Frontiers in cellular neuroscience · 2025Review
- Striatal parvalbumin interneurons are activated in a mouse model of cerebellar dystonia.Disease models & mechanisms · 2024Article
- Sex differences in the distribution and density of regulatory interneurons in the striatum.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in the distribution and density of regulatory interneurons in the striatum.Frontiers in cellular neuroscience · 2024Article
- Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility.The Journal of clinical investigation · 2022Article
- Selective serotonin reuptake inhibitor treatment retunes emotional valence in primate ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- A biologically constrained spiking neural network model of the primate basal ganglia with overlapping pathways exhibits action selection.The European journal of neuroscience · 2021Article
- Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.Nature communications · 2020Article
- Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift.Nature communications · 2020Article
- Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies.Nature communications · 2020Article
- Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement.Nature neuroscience · 2019Article
- Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions.eLife · 2018Article
- Structural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum.The Journal of comparative neurology · 2018Article
- The Input-Output Relationship of the Cholinergic Basal Forebrain.Cell reports · 2017Article
- Differences between Dorsal and Ventral Striatum in the Sensitivity of Tonically Active Neurons to Rewarding Events.Frontiers in systems neuroscience · 2017Article
- Changes in activity of fast-spiking interneurons of the monkey striatum during reaching at a visual target.Journal of neurophysiology · 2017Article
- A Low-Correlation Resting State of the Striatum during Cortical Avalanches and Its Role in Movement Suppression.PLoS biology · 2016Article
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- Spontaneous Synaptic Activation of Muscarinic Receptors by Striatal Cholinergic Neuron Firing.Neuron · 2016Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The striatum is populated by a single projection neuron group, the medium spiny neurons (MSNs), and several groups of interneurons. Two of the electrophysiologically well-characterized striatal interneuron groups are the tonically active neurons (TANs), which are presumably cholinergic interneurons, and the fast spiking interneurons (FSIs), presumably parvalbumin (PV) expressing GABAergic interneurons. To better understand striatal processing it is thus crucial to define the functional relationship between MSNs and these interneurons in the awake and behaving animal. We used multiple electrodes and standard physiological methods to simultaneously record MSN spiking activity and the activity of TANs or FSIs from monkeys engaged in a classical conditioning paradigm. All three cell populations were highly responsive to the behavioral task. However, they displayed different average response profiles and a different degree of response synchronization (signal correlation). TANs displayed the most transient and synchronized response, MSNs the most diverse and sustained response and FSIs were in between on both parameters. We did not find evidence for direct monosynaptic connectivity between the MSNs and either the TANs or the FSIs. However, while the cross correlation histograms of TAN to MSN pairs were flat, those of FSI to MSN displayed positive asymmetrical broad peaks. The FSI-MSN correlogram profile implies that the spikes of MSNs follow those of FSIs and both are driven by a common, most likely cortical, input. Thus, the two populations of striatal interneurons are probably driven by different afferents and play complementary functional roles in the physiology of the striatal microcircuit.
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