ArticleStatistics in medicine2014
Modeling exposure-lag-response associations with distributed lag non-linear models.
Article in Statistics in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 364 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
364 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Effects of controlled, acute exposure to air pollutants on heart rate variability in humans: a meta-regression and methodological recommendations.BMC public health · 2026Pooled it
- Building the model: a review of input structures in extreme temperature-health.Environmental health : a global access science source · 2026Pooled it
- Hourly level analysis of the effects of temperature extremes on emergency ambulance calls.Journal of global health · 2025Pooled it
- Temporal dynamics of early inflammatory markers after professional dental cleaning: a meta-analysis and spline-based meta-regression of TNF-α, IL-1β, IL-6, and (hs)CRP.Frontiers in immunology · 2025Pooled it
- Inverted U-shaped association between bacillary dysentery and temperature: A new finding using a novel two-stage strategy in multi-region studies.PLoS neglected tropical diseases · 2023Pooled it
- Urban heat island impacts on heat-related cardiovascular morbidity: A time series analysis of older adults in US metropolitan areas.Environment international · 2023Pooled it
- Asbestos Consumption and Malignant Mesothelioma Mortality Trends in the Major User Countries.Annals of global health · 2023Pooled it
- Temperature-related mortality and associated vulnerabilities: evidence from Scotland using extended time-series datasets.Environmental health : a global access science source · 2022Pooled it
- Analysis of Firearm Violence During the COVID-19 Pandemic in the US.JAMA network open · 2022Pooled it
- Associations between Legionellosis and meteorological variables in Ohio, 2001-2023.Infectious Disease Modelling · 2026Article
- Association between environmental and headphone noise and heart rate variability: observations from Apple Hearing Study cohort.Journal of exposure science & environmental epidemiology · 2026Article
- The Association Between Ambient Temperature and Hypoglycemia in People Living With Type 1 Diabetes: A Case Time Series Analysis Using Real-Time Continuous Glucose Monitoring.Diabetes care · 2026Article
- Prenatal PMRespirology (Carlton, Vic.) · 2026Article
- Article
- A Mixture of Distributed Lag Non-Linear Models to Account for Spatially Heterogeneous Exposure-Lag-Response Associations.Statistics in medicine · 2026Article
- The impact of improved air quality on low birth weight and health inequalities in Spain from 2010 to 2018.International journal of epidemiology · 2026Article
- Global disparities in COVID-19 vaccine coverage associated with trajectories of SARS-CoV-2 adaptation.BMC infectious diseases · 2026Article
- Modelling the impacts of meteorological factors on herpangina: a Bayesian spatiotemporal analysis.Tropical medicine and health · 2026Article
- Cause-specific heat-related mortality in Rio de Janeiro city: Comparing exposure metrics and the role of exposure duration.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Modeling the Association between Repeated Measures of Hemoglobin during Pregnancy and Adverse Birth Outcomes.The Journal of nutrition · 2026Article
304 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
Abstract
In biomedical research, a health effect is frequently associated with protracted exposures of varying intensity sustained in the past. The main complexity of modeling and interpreting such phenomena lies in the additional temporal dimension needed to express the association, as the risk depends on both intensity and timing of past exposures. This type of dependency is defined here as exposure-lag-response association. In this contribution, I illustrate a general statistical framework for such associations, established through the extension of distributed lag non-linear models, originally developed in time series analysis. This modeling class is based on the definition of a cross-basis, obtained by the combination of two functions to flexibly model linear or nonlinear exposure-responses and the lag structure of the relationship, respectively. The methodology is illustrated with an example application to cohort data and validated through a simulation study. This modeling framework generalizes to various study designs and regression models, and can be applied to study the health effects of protracted exposures to environmental factors, drugs or carcinogenic agents, among others.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.