ArticleClinical pharmacokinetics2013
Amikacin maturation model as a marker of renal maturation to predict glomerular filtration rate and vancomycin clearance in neonates.
Article in Clinical pharmacokinetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Recent advances in the ontogeny of drug disposition.British journal of clinical pharmacology · 2022Review
- Maturation of glomerular filtration rate in neonates and infants: an overview.Pediatric nephrology (Berlin, Germany) · 2021Review
- Drug Elimination Alteration in Acute Lymphoblastic Leukemia Mediated by Renal Transporters and Glomerular Filtration.Pharmaceutical research · 2020Article
- Augmented renal clearance in pediatric intensive care: are we undertreating our sickest patients?Pediatric nephrology (Berlin, Germany) · 2020Review
- Dose Rationale for Amoxicillin in Neonatal Sepsis When Referral Is Not Possible.Frontiers in pharmacology · 2020Article
- Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model.Frontiers in pharmacology · 2020Article
- Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen.Antimicrobial agents and chemotherapy · 2019Article
- A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.The AAPS journal · 2019Article
- Clinical Pharmacokinetics of Amikacin in Pediatric Patients: A Comprehensive Review of Population Pharmacokinetic Analyses.Clinical pharmacokinetics · 2018Review
- Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.CPT: pharmacometrics & systems pharmacology · 2018Article
- Amikacin Pharmacokinetics To Optimize Dosing in Neonates with Perinatal Asphyxia Treated with Hypothermia.Antimicrobial agents and chemotherapy · 2017Article
- Towards Rational Dosing Algorithms for Vancomycin in Neonates and Infants Based on Population Pharmacokinetic Modeling.Antimicrobial agents and chemotherapy · 2016Article
- Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children.Clinical pharmacokinetics · 2015Review
- Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice.Antimicrobial agents and chemotherapy · 2015Article
- Cystatin C as a potential biomarker for dosing of renally excreted drugs.British journal of clinical pharmacology · 2015Review
- Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration.Pharmaceutical research · 2014Article
- Dosage individualization in children: integration of pharmacometrics in clinical practice.World journal of pediatrics : WJP · 2014Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveAmikacin clearance has recently been proposed as a marker of renal maturation in neonates. However, the predictive value of this marker is still unknown. The objective of the present exploratory study was to evaluate the predictive performance of renal maturation model derived from amikacin to predict the glomerular filtration rate (GFR) and vancomycin clearance in neonates.
methodsThe GFR and vancomycin clearance in neonates were predicted using a maturation model derived from amikacin via estimation and simulation in a cohort of 116 neonates using non-linear mixed-effects modeling NONMEM® software.
resultsOur results demonstrate good correlations between predicted and observed GFR and vancomycin clearance in neonates. The square of the correlation coefficient, and means of the prediction error (2.5th-97.5th percentiles) and absolute prediction error (2.5th-97.5th percentiles) are 0.96, 1.2 % (-39.7 to 30.0 %) and 12.3 % (0.4-39.7 %), respectively, for GFR, and 0.97, -11.3 % (-38.2 to 15.4 %) and 14.0 % (0.5-38.2 %), respectively, for vancomycin. The prediction error is not significantly correlated with age.
conclusionAn amikacin maturation model can precisely reflect maturation of glomerular filtration and thus predict the dosage regimens of other renally excreted drugs by glomerular filtration in neonates.
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