ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
Requirement for commissureless2 function during dipteran insect nerve cord development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Preparation and Use of a Yeast shRNA Delivery System for Gene Silencing in Mosquito Larvae.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene.PLoS genetics · 2017Article
- Review
- Redeployment of a conserved gene regulatory network during Aedes aegypti development.Developmental biology · 2016Article
- High-throughput cis-regulatory element discovery in the vector mosquito Aedes aegypti.BMC genomics · 2016Article
- Chitosan/interfering RNA nanoparticle mediated gene silencing in disease vector mosquito larvae.Journal of visualized experiments : JoVE · 2015Article
- Examination of the genetic basis for sexual dimorphism in the Aedes aegypti (dengue vector mosquito) pupal brain.Biology of sex differences · 2014Article
- Developmental neurogenetics of sexual dimorphism inFrontiers in ecology and evolutionArticle
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIn Drosophila melanogaster, commissureless (comm) function is required for proper nerve cord development. Although comm orthologs have not been identified outside of Drosophila species, some insects possess orthologs of Drosophila comm2, which may also regulate embryonic nerve cord development. Here, this hypothesis is explored through characterization of comm2 genes in two disease vector mosquitoes.
resultsCulex quinquefasciatus (West Nile and lymphatic filiariasis vector) has three comm2 genes that are expressed in the developing nerve cord. Aedes aegypti (dengue and yellow fever vector) has a single comm2 gene that is expressed in commissural neurons projecting axons toward the midline. Loss of comm2 function in both A. aegypti and D. melanogaster was found to result in loss of commissure defects that phenocopy the frazzled (fra) loss of function phenotypes observed in both species. Loss of fra function in either insect was found to result in decreased comm2 transcript levels during nerve cord development.
conclusionsThe results of this investigation suggest that Fra down-regulates repulsion in precrossing commissural axons by regulating comm2 levels in both A. aegypti and D. melanogaster, both of which require Comm2 function for proper nerve cord development.
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