ArticleMedical oncology (Northwood, London, England)2013
p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma.
Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review.Chinese journal of cancer · 2017Pooled it
- Prognostic significance of p53 expression in patients with esophageal cancer: a meta-analysis.BMC cancer · 2016Pooled it
- Esophageal Mucosal Resistance in Reflux Esophagitis: What We Have Learned So Far and What Remains to Be Learned.Diagnostics (Basel, Switzerland) · 2023Review
- The High Expression of p53 Is Predictive of Poor Survival RatherJournal of oncology · 2023Article
- Association between TP53 gene deletion and protein expression in esophageal squamous cell carcinoma and its prognostic significance.Oncology letters · 2020Article
- p53 overexpression is a prognosticator of poor outcome in esophageal cancer.Oncology letters · 2019Article
- Large-scale comprehensive immunohistochemical biomarker analyses in esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2017Article
- The Presence of Serum p53 Antibody Predicts the Pathological Tumor Response to Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and Fluorouracil (DCF) in Esophageal Squamous Cell Carcinoma.World journal of surgery · 2017Article
- HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?Infectious agents and cancer · 2017Article
- Potentially Curable Cancers of the Esophagus and Stomach.Mayo Clinic proceedings · 2016Review
- APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2016Article
- p53 is an independent prognostic factor in operable esophageal squamous cell carcinoma: a large-scale study with a long follow-up.Medical oncology (Northwood, London, England) · 2014Article
- Elevated p53 expression levels correlate with tumor progression and poor prognosis in patients exhibiting esophageal squamous cell carcinoma.Oncology letters · 2014Article
- Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities.World journal of gastrointestinal oncology · 2014Review
- Adjuvant chemotherapy, p53, carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma.World journal of gastroenterology · 2014Article
- Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally accepted that overexpression of p53 protein is associated with poor prognosis in gastric, lung, and other types of cancer. However, the prognostic significance of p53 aberrations in esophageal cancer remains unclear. This is the largest study (n = 266) examining clinical and prognostic features of p53 immunohistochemical expression in esophageal squamous cell carcinoma. In 139 (52%) esophageal tumors, nuclear immunoreactivity for p53 protein was detected. p53 aberrant expression was not associated with sex, age, preoperative treatment, TNM stage, or histological grade. Furthermore, p53 expression did not correlate with disease-free survival (P = 0.73) or overall survival (P = 0.62). In addition, no significant modification effect by any of the covariates in the survival analysis was observed (all P > 0.15). In conclusion, our large-scale study demonstrates that p53 expression has no impact on the prognosis of esophageal squamous cell carcinoma.
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