ArticleMedical oncology (Northwood, London, England)2013
Clinical implications of the tumor-infiltrating lymphocyte subsets in colorectal cancer.
Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- The Role of Tumor-Infiltrating B Lymphocytes in Colorectal Cancer Patients: A Systematic Review of Immune Landscape Evolution.Cancers · 2025Review
- Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes.BMC cancer · 2023Article
- Lymphoplasmacyte-rich meningioma with hematologic signs and PD-L1 over-expression.Autopsy & case reports · 2022Article
- Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy.Frontiers in immunology · 2019Review
- Comparative analysis of immune function, hemorheological alterations and prognosis in colorectal cancer patients with different traditional Chinese medicine syndromes.Cancer biomarkers : section A of Disease markers · 2018Article
- The Multifaceted Roles of B Cells in Solid Tumors: Emerging Treatment Opportunities.Targeted oncology · 2017Review
- Increased number of forkhead box P3+ tumor-infiltrating lymphocytes correlates with high preoperative albumin level and better survival in patients with stage II or III colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Prognostic value of CD45RO(+) tumor-infiltrating lymphocytes for locally advanced rectal cancer following 30 Gy/10f neoadjuvant radiotherapy.International journal of colorectal disease · 2015Article
- Relationships between tumor microenvironment and clinicopathological parameters in meningioma.International journal of clinical and experimental pathology · 2014Article
- Landscape of B lymphocytes and plasma cells in digestive tract carcinomas.Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though the total lymphocyte density has been implicated in the pathogenesis of colorectal cancer (CRC), the clinical implications of lymphocyte subsets in CRC patients remain unclear yet. In this study, we used tissue microarrays and immunohistochemistry to evaluate the density of tumor-infiltrating CD4(+) and CD8(+) T cells as well as CD20(+) B cells in the central region and the invasive margin (IM) of tumor tissue from 67 CRC patients and then analyzed the clinical implications. We found that the subsets of tumor-infiltrating lymphocyte had no relationship with patients' age, tumor size, N category, and tumor stage. However, the density of B cells in the tumor center (TC) of colorectal patients in T1/T2 category was much higher than that of patients in T3/T4 category (P = 0.008). In addition, patients in M0 category had a higher density of CD8(+) T cells in the IM but not in the TC compared to patients in M1 category (P = 0.03). Results in this study demonstrate that higher CD8(+) T cell density in the IM of tumor is associated with lower tumor metastasis and higher B cell density in TC is associated with lower tumor T category. The results also suggest that the analysis of infiltrating lymphocyte subsets is important for understanding the detailed mechanisms of tumor pathogenesis and exploring potential interventions for the tumor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.