Observational studyNeurocritical care2014
Safety evaluation of nasopharyngeal cooling (RhinoChill®) in stroke patients: an observational study.
Observational study in Neurocritical care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04973085 (Effect of a Novel Cooling Device on Brain Temperature), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Novel Cooling Device on Brain Temperature
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Therapeutic Hypothermia in Acute Ischemic Stroke-a Systematic Review and Meta-Analysis.Current neurology and neuroscience reports · 2020Pooled it
- Efficacy and Safety of a Nasopharyngeal Catheter for Selective Brain Cooling in Patients with Traumatic Brain Injury: A Prospective, Non-randomized Pilot Study.Neurocritical care · 2021Trial
- Rapid Induction of COOLing in Stroke Patients (iCOOL1): a randomised pilot study comparing cold infusions with nasopharyngeal cooling.Critical care (London, England) · 2014Trial
- Cold stimulation of the oral cavity redistributes blood towards the brain in healthy volunteers.European journal of neurology · 2024Article
- Hypothermia and temperature modulation for intracerebral hemorrhage (ICH): pathophysiology and translational applications.Frontiers in neuroscience · 2024Review
- Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group.Frontiers in neurology · 2022Article
- Selective Brain Cooling: A New Horizon of Neuroprotection.Frontiers in neurology · 2022Review
- Effects of a 4-Step Standard Operating Procedure for the Treatment of Fever in Patients With Acute Stroke.Frontiers in neurology · 2021Article
- Inducing Brain Cooling Without Core Temperature Reduction in Pigs Using a Novel Nasopharyngeal Method: An Effectiveness and Safety Study.Neurocritical care · 2020Article
- A novel selective cooling system for the brain: feasibility study in rabbits vs piglets.Intensive care medicine experimental · 2018Article
- A Novel Cooling Device for Targeted Brain Temperature Control and Therapeutic Hypothermia: Feasibility Study in an Animal Model.Neurocritical care · 2016Article
- In cold blood: intraarteral cold infusions for selective brain cooling in stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation.Frontiers in physiology · 2014Article
- Research progress of selective brain cooling methods in the prehospital care for stroke patients: A narrative review.Brain circulationReview
- Selection of preclinical models to evaluate intranasal brain cooling for acute ischemic stroke.Brain circulationReview
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNew technologies for therapeutic cooling have become available. The objective of our study was to investigate the safety of nasopharyngeal cooling with the RhinoChill(®) device in stroke patients, focusing on systemic and neurovital parameters.
methodsIn this prospective observational study, consecutive patients with severe ischemic or hemorrhagic stroke who underwent intracranial pressure (ICP) and brain temperature monitoring have been enrolled. Ten patients who were treated with the RhinoChill(®) device were analyzed. Brain and bladder temperature and systemic and neurovital parameters were monitored continuously. Additional evaluations of safety included bleeding complications and otolaryngological examinations.
resultsBaseline brain temperature of 36.7 °C (SD 0.9) decreased by an average of 1.21 °C (SD 0.46) within 1 h, the effect of brain temperature decrease ranged from a maximum of 2 °C (patients 3 and 7) to a minimum of 0.6 °C (patient 4). Within the first several minutes after initiating RhinoChill(®) treatment, 3 of 10 patients experienced an increase in systolic arterial pressure by 30, 30, and 53 mmHg, respectively. Heart rate rose as well (mean 3 bpm, SD 2.9). ICP and oxygen saturation were unaffected by the treatment. We observed 1 bleeding complication in the control CT scan of patient 10. Rhinoscopical findings 3 days after nasopharyngeal cooling and at the follow-up (>6 months) and a 16-item smell test were normal.
conclusionThe RhinoChill(®) system cools the brain efficiently. However, steep increases in blood pressure raise serious concerns regarding the safety of its use in stroke patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.