ArticlePsychopharmacology2014
Pavlovian conditioned approach, extinction, and spontaneous recovery to an audiovisual cue paired with an intravenous heroin infusion.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Investigating discriminative stimulus modulation of opioid seeking after conflict-induced abstinence in sign- and goal-tracking rats.Psychopharmacology · 2022Article
- Ethanol-paired stimuli can increase reinforced ethanol responding.Alcohol (Fayetteville, N.Y.) · 2020Article
- Acute ovarian hormone treatment in freely cycling female rats regulates distinct aspects of heroin seeking.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Effects of rat strain and method of inducing ethanol drinking on Pavlovian-Instrumental-Transfer with ethanol-paired conditioned stimuli.Alcohol (Fayetteville, N.Y.) · 2019Article
- Nicotine-enhanced Pavlovian conditioned approach is resistant to omission of expected outcome.Behavioural brain research · 2018Article
- Sex and Adolescent Ethanol Exposure Influence Pavlovian Conditioned Approach.Alcoholism, clinical and experimental research · 2017Article
- Effects of an ethanol-paired CS on responding for ethanol and food: Comparisons with a stimulus in a Truly-Random-Control group and to a food-paired CS on responding for food.Alcohol (Fayetteville, N.Y.) · 2016Article
- Conditioned stimuli's role in relapse: preclinical research on Pavlovian-Instrumental-Transfer.Psychopharmacology · 2016Review
- Individual variation in the motivational properties of a nicotine cue: sign-trackers vs. goal-trackers.Psychopharmacology · 2015Article
- Individual variation in the motivational and neurobiological effects of an opioid cue.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Isolating the incentive salience of reward-associated stimuli: value, choice, and persistence.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- The attribution of incentive salience to Pavlovian alcohol cues: a shift from goal-tracking to sign-tracking.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleNovel stimuli paired with exposure to addictive drugs can elicit approach through Pavlovian learning. While such approach behavior, or sign tracking, has been documented for cocaine and alcohol, it has not been shown to occur with opiate drugs like heroin. Most Pavlovian conditioned approach paradigms use an operandum as the sign, so that sign tracking can be easily automated.
objectivesWe were interested in assessing whether approach behavior occurs to an audiovisual cue paired with an intravenous heroin infusion. If so, would this behavior exhibit characteristics of other Pavlovian conditioned behaviors, such as extinction and spontaneous recovery?
methodsRats were repeatedly exposed to an audiovisual cue, similar to that used in standard self-administration models, along with an intravenous heroin infusion. Sign tracking was measured in an automated fashion by analyzing motion pixels within the cue zone during each cue presentation.
resultsWe were able to observe significant sign tracking after only five pairings of the conditioned stimulus (CS) with the unconditioned stimulus (US). This behavior rapidly extinguished over 2 days, but exhibited pronounced spontaneous recovery 3 weeks later.
conclusionsWe conclude that sign tracking measured by these methods exhibits all the characteristics of a classically conditioned behavior. This model can be used to examine the Pavlovian component of drug memories, alone, or in combination with self-administration methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.