ArticleAmerican journal of epidemiology2013
Elevated high-sensitivity C-reactive protein as a risk marker of the attenuated relationship between serum cholesterol and cardiovascular events at older age. The ARIC Study.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Regional variations in cardiovascular risk predictions: a comparative analysis of Framingham, SCORE2, and WHO models across 53 countries.Journal of global health · 2025Article
- Concordant and discordant roles of remnant cholesterol and hs-CRP in cardiovascular disease; gender stratified analysis.Lipids in health and disease · 2025Article
- How does biological age acceleration mediate the associations of obesity with cardiovascular disease? Evidence from international multi-cohort studies.Cardiovascular diabetology · 2025Article
- 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.Acta Cardiologica Sinica · 2024Article
- Association Between High-Sensitivity C-Reactive Protein (hs-CRP) Levels With Lipids and Micronutrients.Cureus · 2024Article
- Validation of the European SCORE2 models in a Canadian primary care cohort.European journal of preventive cardiology · 2024Article
- Serum Albumin was Associated with a Long Term Cardiovascular Mortality among Elderly Patients with Stable Coronary Artery Disease.Acta Cardiologica Sinica · 2024Article
- Risk Factors for Incident Coronary Artery Calcium in Younger (Age 32 to 45 Years) Versus Intermediate (46 to 64 Years) Versus Older (65 to 84 Years) Persons.The American journal of cardiology · 2022Article
- Cardiovascular risk and metabolic profile of Polish citizens from Lower Silesia. First signs of metabolic crisis?Archives of medical science : AMS · 2022Article
- Cardiovascular risk and aging: the need for a more comprehensive understanding.Journal of geriatric cardiology : JGC · 2021Article
- Cardiovascular Biomarkers and Imaging in Older Adults: JACC Council Perspectives.Journal of the American College of Cardiology · 2020Review
- High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular Disease: A Nested Case Control from Isfahan Cohort Study (ICS).Global heart · 2020Article
- Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study.American journal of preventive medicine · 2020Article
- A Control-Theoretic Model of Atherosclerosis.International journal of molecular sciences · 2019Article
- Cardiovascular risk prediction in older adults with the use of biomarkers.Annals of translational medicine · 2018Article
- Short-Term Global Cardiovascular Disease Risk Prediction in Older Adults.Journal of the American College of Cardiology · 2018Observational
- Galectin-3 and Venous Thromboembolism Incidence: the Atherosclerosis Risk in Communities (ARIC) Study.Research and practice in thrombosis and haemostasis · 2017Article
- Galectin-3 and incidence of atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study.American heart journal · 2017Article
- Sex Differences in the Association between Traditional Vascular Risk Factors and Subclinical Carotid Atherosclerosis in Taiwan.Journal of atherosclerosis and thrombosis · 2017Article
- Synergistic and Non-synergistic Associations for Cigarette Smoking and Non-tobacco Risk Factors for Cardiovascular Disease Incidence in the Atherosclerosis Risk In Communities (ARIC) Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The relationship between cholesterol and coronary heart disease (CHD) is attenuated at older age. We analyzed cholesterol level as a predictor of CHD in 8,947 participants from the Atherosclerosis Risk in Communities (ARIC) Study, a large multicenter cohort study that enrolled participants in 1987-1989 at 4 field centers in Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and Minneapolis, Minnesota. Participants in the present analysis had no history of CHD and were stratified by age (<65 or ≥65 years) and high-sensitivity C-reactive protein (hs-CRP) level (<2 or ≥2 mg/L). Visit 4 (1996-1997) was the baseline for this analysis, with follow-up through 2008. Cholesterol level was significantly associated with CHD among younger participants, and cholesterol level was similarly predictive of CHD among older participants with an hs-CRP level of <2 mg/L. In contrast, among older participants with an hs-CRP level of 2 mg/L or higher, the association of CHD with total cholesterol level was borderline significant (hazard ratio = 1.14, 95% confidence interval: 1.00, 1.29), and the association of CHD with low-density lipoprotein cholesterol level was nonsignificant (hazard ratio = 1.10; 95% confidence interval: 0.96, 1.26). Among older persons with an elevated hs-CRP level, cholesterol level was significantly less predictive of CHD (P < 0.05), whereas for those with an hs-CRP level of <2 mg/L, there was no significant difference compared with younger participants. In conclusion, we found that among the young-old, the association of cholesterol level with CHD was strong when hs-CRP level was not elevated and weak when hs-CRP level was elevated. Therefore, hs-CRP level could be useful for stratifying the young-old to assess the strength of cholesterol level in CHD risk prediction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.