Trial reportSpine2013
Design of the Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST).
Trial report in Spine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00448448 (Bracing in Adolescent Idiopathic Scoliosis Trial), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST)
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Braces for idiopathic scoliosis in adolescents.The Cochrane database of systematic reviews · 2015Pooled it
- Nighttime Bracing or Exercise in Moderate-Grade Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial.JAMA network open · 2024Trial
- A United States multi-site randomized control trial of Schroth-based therapy in adolescents with mild idiopathic scoliosis.Spine deformity · 2023Trial
- Body Image and Quality of Life and Brace Wear Adherence in Females With Adolescent Idiopathic Scoliosis.Journal of pediatric orthopedics · 2017Trial
- Trial
- Effects of bracing in adolescents with idiopathic scoliosis.The New England journal of medicine · 2013Trial
- Seasonal and Temporal Patterns of Brace-Wearing Behavior in Adolescent Idiopathic Scoliosis Assessed Using Objective Sensor Data.Medicina (Kaunas, Lithuania) · 2026Observational
- Brace Treatment Is Associated with Lower Curve Progression in Moderate Adolescent Idiopathic Scoliosis, While Psychosocial Outcomes Are Driven by Depressive Symptoms and Curve Progression.Journal of clinical medicine · 2026Article
- Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Musculoskeletal Disorders.Acta medica Philippina · 2026Article
- Brace yourself (Part-time): part-time bracing leads to curve improvement in juvenile idiopathic scoliosis.Spine deformity · 2026Article
- Integrating intrinsic musculoskeletal pathology and genetics: Recent advances in unravelling the causative factors of adolescent idiopathic scoliosis.Bone reports · 2025Review
- Impact of Baseline HRQOL on Brace-Related Stress in Female Patients with Adolescent Idiopathic Scoliosis: A Longitudinal Retrospective Study.Spine surgery and related research · 2025Article
- Assessment and Management of Adolescent Idiopathic Scoliosis: From the Perspective of a Physiatrist.Annals of rehabilitation medicine · 2025Article
- To Screen or Not to Screen: "False Positive" Cases-Can They Be Treated as Definitely False? Properly Selecting the Screening Age-Range Groups in Scoliosis Screening Programs.Healthcare (Basel, Switzerland) · 2025Article
- Discontinuation of brace treatment in adolescent idiopathic scoliosis (AIS): a scoping review.Spine deformity · 2024Article
- The Improvement of Trunk Muscle Endurance in Adolescents with Idiopathic Scoliosis Treated with ScoliBraceJournal of clinical medicine · 2024Article
- Optimized braces for the treatment of adolescent idiopathic scoliosis: A study protocol of a prospective randomised controlled trial.PloS one · 2024Article
- The natural history of curve behavior after brace removal in adolescent idiopathic scoliosis: a literature review.Spine deformity · 2023Review
- Intensive bracing management combined with physiotherapeutic scoliosis-specific exercises for adolescent idiopathic scoliosis patients with a major curve ranging from 40-60° who refused surgery: a prospective cohort study.European journal of physical and rehabilitation medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
STUDY
designDescriptive.
objectiveTo describe the design and development of Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST). SUMMARY OF BACKGROUND DATA: Bracing has remained the standard of care for the nonoperative treatment of adolescent idiopathic scoliosis since the introduction of the Milwaukee brace in the late 1940s, but it has never been subjected to a rigorous evaluation of either its efficacy or its effectiveness. The BrAIST was designed to address the primary question: Do braces (specifically a thoracolumbosacral orthosis) lower the risk of curve progression to a surgical threshold (≥50°) in patients with adolescent idiopathic scoliosis relative to watchful waiting alone?
methodsThe authors describe the rationale for BrAIST, including the limitations of the current literature evaluating bracing for adolescent idiopathic scoliosis. Second, the authors describe the preliminary work, including the preparation of the National Institutes of Health clinical trials planning grant. Finally, the authors describe the trial design in detail.
resultsBrAIST was conducted in 25 sites in North America. Subjects were treated either with a thoracolumbosacral orthosis or watchful waiting and followed every 6 months until they reached skeletal maturity or the surgical threshold of 50° Cobb angle.
conclusionClinical decision making will be improved by translation of the BrAIST results into evidence-based prognosis and estimates of how the prognosis, specifically the risk of progressing to surgery, may be altered by the use of bracing. LEVEL OF EVIDENCE: N/A.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.