ArticleDevelopment (Cambridge, England)2013
midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Integrator subunit IntS11 orchestrates the temporal dynamics of neural lineage progression in Drosophila.Cell & bioscience · 2026Article
- Unveiling the functional fate of duplicated genes through expression profiling and structural analysis.Genome research · 2025Article
- The TRIM-NHL RNA-binding protein MEI-P26 modulates the size of Drosophila Type I neuroblast lineages.Genetics · 2025Article
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- The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis.eLife · 2024Article
- Prognostic value of RNF113A shows a correlation with immune infiltrates in colorectal cancer.American journal of translational research · 2024Article
- Mutations in abnormal spindle disrupt temporal transcription factor expression and trigger immune responses in the Drosophila brain.Genetics · 2023Article
- Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina.PLoS genetics · 2023Article
- Maintenance of neuronal fate and transcriptional identity.Biology open · 2023Review
- Dedifferentiation-derived neural stem cells exhibit perturbed temporal progression.EMBO reports · 2023Article
- ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export.EMBO reports · 2022Article
- Article
- Sustained expression ofeLife · 2021Article
- Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation.Biology open · 2020Article
- A novel truncating variant in ring finger protein 113A (RNF113A) confirms the association of this gene with X-linked trichothiodystrophy.American journal of medical genetics. Part A · 2020Article
- Fzr/Cdh1 Promotes the Differentiation of Neural Stem Cell Lineages inFrontiers in cell and developmental biology · 2020Article
- Functional analysis of Cwc24 ZF-domain in 5' splice site selection.Nucleic acids research · 2019Article
- Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in theThe EMBO journal · 2019Article
- Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System.Journal of developmental biology · 2018Review
- Drosophila nucleostemin 3 is required to maintain larval neuroblast proliferation.Developmental biology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stem cells generate progeny that undergo terminal differentiation. The initiation and maintenance of the differentiated status is crucial for tissue development, function and homeostasis. Drosophila neural stem cells (neuroblasts) are a model for stem cell self-renewal and differentiation; they divide asymmetrically to self-renew and generate the neurons and glia of the CNS. Here we report the identification of midlife crisis (mdlc; CG4973) as a gene required for the maintenance of neuronal differentiation and for neuroblast proliferation in Drosophila. mdlc encodes a ubiquitously expressed zinc-finger-containing protein with conserved orthologs from yeast to humans that are reported to have a role in RNA splicing. Using clonal analysis, we demonstrate that mdlc mutant neurons initiate but fail to complete differentiation, as judged by the loss of the pro-differentiation transcription factor Prospero, followed by derepression of the neuroblast factors Deadpan, Asense and Cyclin E. RNA-seq shows that loss of Mdlc decreases pros transcript levels and results in aberrant pros splicing. Importantly, misexpression of the full-length human ortholog, RNF113A, completely rescues all CNS defects in mdlc mutants. We conclude that Mdlc plays an essential role in maintaining neuronal differentiation, raising the possibility that RNF113A regulates neuronal differentiation in the human CNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.