ArticleGenetics2013
Hot regions of noninterfering crossovers coexist with a nonuniformly interfering pathway in Arabidopsis thaliana.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Interference length reveals regularity of crossover placement across species.Nature communications · 2024Article
- Genetic background affects the strength of crossover interference in house mice.bioRxiv : the preprint server for biology · 2024Article
- Predicting recombination suppression outside chromosomal inversions in Drosophila melanogaster using crossover interference theory.Heredity · 2023Article
- A Novel Strategy to Reveal the Landscape of Crossovers in an F1 Hybrid Population ofPlants (Basel, Switzerland) · 2022Article
- CDKG1 Is Required for Meiotic and Somatic Recombination Intermediate Processing in Arabidopsis.The Plant cell · 2020Article
- Crossover Interference: Shedding Light on the Evolution of Recombination.Annual review of genetics · 2019Review
- Modelling Sex-Specific Crossover Patterning inGenetics · 2019Article
- Single gametophyte sequencing reveals that crossover events differ between sexes in maize.Nature communications · 2019Article
- Role ofGenetics · 2018Article
- Article
- Linkage Mapping Reveals Strong Chiasma Interference in Sockeye Salmon: Implications for Interpreting Genomic Data.G3 (Bethesda, Md.) · 2015Article
- Modulating crossover positioning by introducing large structural changes in chromosomes.BMC genomics · 2015Article
- Punctuated distribution of recombination hotspots and demarcation of pericentromeric regions in Phaseolus vulgaris L.PloS one · 2015Article
- Crossover localisation is regulated by the neddylation posttranslational regulatory pathway.PLoS biology · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most organisms that have been studied, crossovers formed during meiosis exhibit interference: nearby crossovers are rare. Here we provide an in-depth study of crossover interference in Arabidopsis thaliana, examining crossovers genome-wide in >1500 backcrosses for both male and female meiosis. This unique data set allows us to take a two-pathway modeling approach based on superposing a fraction p of noninterfering crossovers and a fraction (1 - p) of interfering crossovers generated using the gamma model characterized by its interference strength nu. Within this framework, we fit the two-pathway model to the data and compare crossover interference strength between chromosomes and then along chromosomes. We find that the interfering pathway has markedly higher interference strength nu in female than in male meiosis and also that male meiosis has a higher proportion p of noninterfering crossovers. Furthermore, we test for possible intrachromosomal variations of nu and p. Our conclusion is that there are clear differences between left and right arms as well as between central and peripheral regions. Finally, statistical tests unveil a genome-wide picture of small-scale heterogeneities, pointing to the existence of hot regions in the genome where crossovers form preferentially without interference.
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