ArticleMolecular biology and evolution2013
Substantial loss of conserved and gain of novel MicroRNA families in flatworms.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 97 citations in OpenAlex.
- Selective Packaging of miR-22 and miR-29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis.Journal of extracellular vesicles · 2026Article
- Repeated emergence of giant microRNA hairpins across invertebrates.Cell reports · 2025Article
- Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents.BMC genomics · 2025Article
- Substantial Hierarchical Reductions of Genetic and Morphological Traits in the Evolution of Rotiferan Parasites.Genome biology and evolution · 2025Article
- MirGeneDB 3.0: improved taxonomic sampling, uniform nomenclature of novel conserved microRNA families and updated covariance models.Nucleic acids research · 2025Article
- Exploring extracellular vesicles in zoonotic helminth biology: implications for diagnosis, therapeutic and delivery.Frontiers in cellular and infection microbiology · 2024Review
- Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine.Cell genomics · 2023Article
- Direct observation of the evolution of cell-type-specific microRNA expression signatures supports the hematopoietic origin model of endothelial cells.Evolution & development · 2023Article
- Small RNAs in Cnidaria: A review.Evolutionary applications · 2023Article
- Parasitic plant small RNA analyses unveil parasite-specific signatures of microRNA retention, loss, and gain.Plant physiology · 2022Article
- Cestodes in the genomic era.Parasitology research · 2022Review
- MirGeneDB 2.1: toward a complete sampling of all major animal phyla.Nucleic acids research · 2022Article
- Parasite-derived microRNAs as a diagnostic biomarker: potential roles, characteristics, and limitations.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Review
- Large-Scale Annotation and Evolution Analysis of MiRNA in Insects.Genome biology and evolution · 2021Article
- Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro.PLoS neglected tropical diseases · 2021Article
- Isolation and Analysis of MicroRNAs from Extracellular Vesicles of the Parasitic Model Nematodes Nippostrongylus brasiliensis and Trichuris muris.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Role ofFrontiers in cellular and infection microbiology · 2021Article
- Lost and Found: Piwi and Argonaute Pathways in Flatworms.Frontiers in cellular and infection microbiology · 2021Article
- An Evaluation of theFrontiers in immunology · 2020Review
- MicroRNAs: From Mechanism to Organism.Frontiers in cell and developmental biology · 2020Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies on microRNA (miRNA) evolution focused mainly on the comparison of miRNA complements between animal clades. However, evolution of miRNAs within such groups is poorly explored despite the availability of comparable data that in some cases lack only a few key taxa. For flatworms (Platyhelminthes), miRNA complements are available for some free-living flatworms and all major parasitic lineages, except for the Monogenea. We present the miRNA complement of the monogenean flatworm Gyrodactylus salaris that facilitates a comprehensive analysis of miRNA evolution in Platyhelminthes. Using the newly designed bioinformatics pipeline miRCandRef, the miRNA complement was disentangled from next-generation sequencing of small RNAs and genomic DNA without a priori genome assembly. It consists of 39 miRNA hairpin loci of conserved miRNA families, and 22 novel miRNAs. A comparison with the miRNA complements of Schmidtea mediterranea (Turbellaria), Schistosoma japonicum (Trematoda), and Echinococcus granulosus (Cestoda) reveals a substantial loss of conserved bilaterian, protostomian, and lophotrochozoan miRNAs. Eight of the 46 expected conserved miRNAs were lost in all flatworms, 16 in Neodermata and 24 conserved miRNAs could not be detected in the cestode and the trematode. Such a gradual loss of miRNAs has not been reported before for other animal phyla. Currently, little is known about miRNAs in Platyhelminthes, and for the majority of the lost miRNAs there is no prediction of function. As suggested earlier they might be related to morphological simplifications. The presence and absence of 153 conserved miRNAs was compared for platyhelminths and 32 other metazoan taxa. Phylogenetic analyses support the monophyly of Platyhelminthes (Turbellaria + Neodermata [Monogenea {Trematoda + Cestoda}]).
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