ReviewMalaria journal2013
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria.
Review in Malaria journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Who cites it
44 citing papers in PubMed.
- Impact of Sickle Cell Hemoglobin Genotypes on Clinical Outcomes AmongHealth science reports · 2026Article
- Elevated Plasmodium falciparum sexual conversion in HbAC and HbAS red blood cells in naturally infected malaria patients.PLoS pathogens · 2026Article
- Data-driven spatial-temporal framework for exploring the heterogeneity and temporality of sepsis.Chinese medical journal · 2026Review
- Pyogenic Splenic Abscess With Concurrent Active Plasmodium falciparum Malaria and Sickle Cell Trait: A Case Report.Cureus · 2026Article
- Sickle Cell Anemia and Inflammation: A Review of Stones and Landmarks Paving the Road in the Last 25 Years.Hematology reports · 2025Review
- Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism.Pathogens (Basel, Switzerland) · 2024Article
- Characterizing the pathogenicity of genetic variants: the consequences of context.NPJ genomic medicine · 2024Article
- Natural killer cell antibody-dependent cellular cytotoxicity toClinical & translational immunology · 2024Article
- Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya.BMC cancer · 2023Article
- Influence of the sickle cell trait on Plasmodium falciparum infectivity from naturally infected gametocyte carriers.BMC infectious diseases · 2023Article
- Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups.BMC nutrition · 2023Article
- Elucidating parasite and host-cell factors enabling Babesia infection in sickle red cells under hypoxic/hyperoxic conditions.Blood advances · 2023Article
- Eryptosis as a New Insight in Malaria Pathogenesis.Frontiers in immunology · 2022Review
- Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor.Nature biomedical engineering · 2021Article
- Non-S Sickling Hemoglobin Variants: Historical, Genetic, Diagnostic, and Clinical Perspectives.Oman medical journal · 2021Review
- Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya.BMC infectious diseases · 2020Article
- Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types.Malaria journal · 2020Article
- Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.Malaria journal · 2020Article
- Sickle Cell Trait Induces Oxidative Damage onInternational journal of molecular sciences · 2019Article
- Altered parasite life-cycle processes characterizeHaematologica · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria.
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