SynthesisThe American journal of clinical nutrition2013
Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population.
Synthesis in The American journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Diet and Risk of Gastric Cancer: An Umbrella Review.Nutrients · 2022Pooled it
- An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.Cancer causes & control : CCC · 2016Pooled it
- The Effect of Anthocyanins on Blood Pressure: A PRISMA-Compliant Meta-Analysis of Randomized Clinical Trials.Medicine · 2016Pooled it
- Prospective study of Helicobacter pylori antigens and gastric noncardia cancer risk in the nutrition intervention trial cohort.International journal of cancer · 2015Pooled it
- Association between vitamin C intake and lung cancer: a dose-response meta-analysis.Scientific reports · 2014Pooled it
- Vitamin intake reduce the risk of gastric cancer: meta-analysis and systematic review of randomized and observational studies.PloS one · 2014Pooled it
- Association Between Lifestyle Factors, Vitamin and Garlic Supplementation, and Gastric Cancer Outcomes: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2020Trial
- A prospective study of vitamin and mineral supplement use and the risk of upper gastrointestinal cancers.PloS one · 2014Trial
- The role of diet in cancer: the potential of shaping public policy and clinical outcomes in the UK.Genes & nutrition · 2024Review
- Review
- Mild Vitamin C Deficiency Is Common in the Inpatient Psychiatric Setting.The Journal of clinical psychiatry · 2023Article
- Review
- Vitamin C fortification: need and recent trends in encapsulation technologies.Frontiers in nutrition · 2023Review
- Genetically predicted vitamin C levels significantly affect patient survival and immunotypes in multiple cancer types.Frontiers in immunology · 2023Article
- Association between Micronutrient Intake and Breast Cancer Risk According to Body Mass Index in South Korean Adult Women: A Cohort Study.Nutrients · 2022Article
- Overview ofDiseases (Basel, Switzerland) · 2021Review
- Review
- Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective.Nutrients · 2020Review
- Diet, nutrition, and cancer risk: what do we know and what is the way forward?BMJ (Clinical research ed.) · 2020Article
- Association of plasma vitamin C concentration to total and cause-specific mortality: a 16-year prospective study in China.Journal of epidemiology and community health · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 4 countries.
Funding
Abstract
backgroundChina has some of the highest incidence rates for gastric adenocarcinoma (GA) and esophageal squamous cell carcinoma (ESCC) in the world. Prospective studies suggested that vitamin C may reduce risks; however, associations are unclear because of limited sample size.
objectiveThe objective was to examine the relation between prediagnostic plasma vitamin C and the risk of GA and ESCC.
designA case-cohort study was used to assess the association between prediagnostic plasma vitamin C and incidence of GA (n = 467) and ESCC (n = 618) in the General Population Nutrition Intervention Trial. With the use of multivariate Cox proportional hazards models, we estimated the HRs and 95% CIs. We also conducted a meta-analysis of the literature up to 1 October 2012 on the relation between circulating vitamin C and gastric cancer incidence. Two cohort studies and the current study were included to assess the body of evidence.
resultsFor GA, each 20-μmol/L increase in plasma vitamin C was associated with a 14% decrease in risk (HR: 0.86; 95% CI: 0.76, 0.96). Compared with individuals with low plasma vitamin C concentrations (≤28 μmol/L), those with normal concentrations (>28 μmol/L) had a 27% reduced risk of GA (HR: 0.73; 95% CI: 0.56, 0.94). No association between vitamin C concentrations and ESCC was seen. Meta-analysis showed that the risk of incident GA among those with the highest concentration of plasma vitamin C was 31% lower (random-effects-pooled-odds ratio 0.69; 95% CI: 0.54, 0.89) than those in the lowest category.
conclusionOur data provide evidence that higher circulating vitamin C was associated with a reduced risk of incident GA, but no association was seen for ESCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.