ArticleBMC medical ethics2013
Taking part in a pharmacogenetic clinical trial: assessment of trial participants understanding of information disclosed during the informed consent process.
Article in BMC medical ethics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Measuring and evaluating participant understanding of consent processes in clinical trials: a systematic review.Trials · 2026Pooled it
- A stepwise approach to implementing pharmacogenetic testing in the primary care setting.Pharmacogenomics · 2019Article
- Ethical Issues of Using CRISPR Technologies for Research on Military Enhancement.Journal of bioethical inquiry · 2018Review
- Abandoning personalization to get to precision in the pharmacotherapy of depression.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Within and beyond the communal turn to informed consent in industry-sponsored pharmacogenetics research: merits and challenges of community advisory boards.Journal of community genetics · 2016Review
- A review of consent practices and perspectives for pharmacogenetic testing.Pharmacogenomics · 2016Review
- Service users' and carers' views on research towards stratified medicine in psychiatry: a qualitative study.BMC research notes · 2015Article
- Pharmacogenetic information for patients on drug labels.Pharmacogenomics and personalized medicine · 2014Article
- Why parents consent to their children's participation in genetic research: A study of parental decision making.Indian journal of medical ethicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study is the first to examine the understandings that participants have of the consent process in a pharmacogenetic trial of anti-depressant medication.
methodsThis was a qualitative cross sectional study. There were 76 participants residing in London, Mannheim, Arhuus and Poznan.
resultsOnly one quarter of participants (none in Poznan) could articulate the concept of pharmacogenetics. Heritability and testing medication were also given as the purpose of the trial. Most participants had not appreciated harms that could derive from the trial. Even when shown the consent sheet, participants were confused about DNA profiling. There was evidence that participants appreciated weekly contact with researchers. Most said they would participate in a trial again but would like choice over the intervention they were assigned to.
conclusionParticipants in this study showed a poor level of informed consent. Although this is not the first time this argument has been made, it is in the case of a pharmacogenetic trial. Further work should investigate the associations between extraneous factors such as information and social support on beneficial or untoward outcomes of antidepressant treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.