ArticleRNA biology2013
Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues.
Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis.The Journal of experimental medicine · 2025Article
- ADAR2-mediated Q/R editing of GluA2 in homeostatic synaptic plasticity.Science signaling · 2025Article
- Phylogenetic and structural analysis of Hydra ADAR.Archives of biochemistry and biophysics · 2025Article
- RNA editing in disease: mechanisms and therapeutic potential.RNA (New York, N.Y.) · 2025Review
- RNA Pol II-dependent transcription efficiency fine-tunes A-to-I editing levels.Genome research · 2024Article
- Article
- Filamin A pre-mRNA editing modulates vascularization and tumor growth.Molecular therapy. Nucleic acids · 2022Article
- A-to-I RNA editing of Filamin A regulates cellular adhesion, migration and mechanical properties.The FEBS journal · 2022Article
- ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway.Life science alliance · 2022Article
- RNA editing of ion channels and receptors in physiology and neurological disorders.Oxford open neuroscience · 2022Review
- Epitranscriptomics of cardiovascular diseases (Review).International journal of molecular medicine · 2022Review
- Review
- Endogenous Double-Stranded RNA.Non-coding RNA · 2021Review
- Conservation of A-to-I RNA editing in bowhead whale and pig.PloS one · 2021Article
- Increased RNA editing in maternal immune activation model of neurodevelopmental disease.Nature communications · 2020Article
- ADAR-deficiency perturbs the global splicing landscape in mouse tissues.Genome research · 2020Article
- A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing.RNA (New York, N.Y.) · 2020Article
- A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing.Genome research · 2019Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RNA editing by ADARs can change the coding potential of protein-coding mRNAs. So far, this type of RNA editing has mainly been shown to affect RNAs expressed in the nervous system with much lower editing levels being observed in other tissues. The actin crosslinking proteins filamin α and filamin β are widely expressed in most tissues. The mRNAs encoding either protein are edited at the same position leading to a conserved Q to R exchange in both proteins. Using bar-coded next generation sequencing, we show that editing of filamin α is most abundant in the gastrointestinal tract and only to a lesser extent in the nervous system. Using knockout mice, we show that ADARB1 (ADAR2) is responsible for the majority of FLNA editing, while ADAR1 can edit filamin α mRNA in some tissues quite efficiently. Interestingly, editing levels of filamin α and β do not follow the same trend across tissues, suggesting a substrate-specific regulation of editing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.