ArticleInternational journal of molecular sciences2013
Distribution of alpha thalassaemia gene variants in diverse ethnic populations in malaysia: data from the institute for medical research.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Thalassemia and hemoglobinopathy prevalence in a community-based sample in Sylhet, Bangladesh.Orphanet journal of rare diseases · 2023Trial
- Molecular profiling of thalassemia in Southeastern Romania.Journal of hematopathology · 2026Article
- Alpha-thalassaemia early eluting peak for alpha-thalassaemia --Annals of hematology · 2026Article
- Determination of mean corpuscular haemoglobin cut-off point for differentiating alpha plus and alpha zero thalassaemia in thalassaemia screening.Annals of hematology · 2026Article
- Prevalence of Severe Thalassemia and Performance of Prenatal Screening Tests Among Pregnant Women at Siriraj Thalassemia Center in Thailand.Clinical and translational science · 2026Article
- Genetic analysis of thalassemia in putian: comparative insights into mutation spectra with other global regions.Annals of hematology · 2025Article
- The Clinical and Laboratory Profiles of a Deletional α2-Globin Gene Polyadenylation Signal Sequence (AATAAA > AATA--) [HBA2:c.*93_*94delAA]: The Malaysian Experience.Diagnostics (Basel, Switzerland) · 2025Article
- Prevalence and molecular spectrum of thalassemia in infertile population among different ethnic groups in Hainan Province, China.Molecular genetics and genomics : MGG · 2025Article
- Diagnostic Utility of a Multiplex PCR Assay in Detecting Common Mutations of the α-Globin Gene in α-Thalassemia.Anemia · 2025Article
- Hematologic Parameters Cut-off Assessment of Adult Alpha-Thalassemia Patients in Iran.International journal of hematology-oncology and stem cell research · 2024Article
- Hematological Profile of Hb Adana Among High School Students in Northeast Peninsular Malaysia.Cureus · 2024Article
- Characterization of New Alpha Zero (αDiagnostics (Basel, Switzerland) · 2023Article
- Significance of Zone 2 Peak on Capillary Electrophoresis in the Detection of Hemoglobin Constant Spring.Oman medical journal · 2023Article
- Gene Mutation Spectrum among Alpha-Thalassaemia Patients in Northeast Peninsular Malaysia.Diagnostics (Basel, Switzerland) · 2023Article
- Knowledge and attitudes of thalassaemia among high-risk indigenous university students in Bangladesh: A pilot study.PloS one · 2023Article
- Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry.BMJ open · 2020Observational
- Prevalence of 3.7 and 4.2 deletions in Sudanese patients with red cells hypochromia and microcytosis.BMC research notes · 2020Article
- Prenatal diagnosis of α- and β-thalassemias in southern Thailand.International journal of hematology · 2020Article
- Cut-Off Values of Hematologic Parameters to Predict the Number of Alpha Genes Deleted in Subjects with Deletional Alpha Thalassemia.International journal of molecular sciences · 2017Article
- DNA studies are necessary for accurate patient diagnosis in compound heterozygosity for Hb Adana (HBA2:c.179>A) with deletional or nondeletional α-thalassaemia.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this retrospective analysis were to describe the distribution of various alpha thalassaemia alleles in different ethnic groups, along with their genotypic interactions, and to illustrate the haematological changes associated with each phenotype. Amongst the patients, 51.2% (n = 2567) were diagnosed with α thalassaemia. Of the 13 α thalassaemia determinants screened, eight different deletions and mutations were demonstrated: three double gene deletions, --(SEA), --(THAI), --(FIL); two single-gene deletions, α-³·⁷ and -α⁴·²; and three non-deletion mutations, Cd59G > A (haemoglobin [Hb] Adana), Cd125T > C (Hb Quong Sze) and Cd142 (Hb Constant Spring). A high incidence of α-³·⁷ deletion was observed in Malays, Indians, Sabahans, Sarawakians and Orang Asli people. However, the --SEA deletion was the most common cause of alpha thalassaemia in Chinese, followed by the α-³·⁷ deletion. As many as 27 genotypic interactions showed 1023 α thalassaemia silent carriers, 196 homozygous α⁺ thalassaemia traits, 973 heterozygous α⁰ thalassaemia carriers and 375 patients with Hb H disease. Statistical analysis showed a significant difference in the distribution of α thalassaemia determinants amongst the various ethnic groups. Hence, the heterogeneous distribution of common determinants indicated that the introduction of an ethnicity-targeted hierarchical α thalassaemia screening approach in this multi-ethnic Malaysian population would be effective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.