Evidence map›Paper›PMID 24025411›Full record

ReviewCancer biology & therapy2013

Advances in the understanding of the Fanconi anemia tumor suppressor pathway.

Anna Pickering, Jun Zhang, Jayabal Panneerselvam, Peiwen Fei

Abstract readReview
In one paragraph

Review in Cancer biology & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Focal Point of Fanconi Anemia Signaling.International journal of molecular sciences · 2021
    Review
  4. Review
  5. FANCD2 and DNA Damage.International journal of molecular sciences · 2017
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna PickeringUniversity of Hawaii Cancer Center; University of Hawaii; Honolulu, HI USA.
Jun ZhangDepartment of Laboratory Medicine and Pathology; Mayo Clinic; Rochester, MN USA.
Jayabal PanneerselvamUniversity of Hawaii Cancer Center; University of Hawaii; Honolulu, HI USA.
Peiwen FeiUniversity of Hawaii Cancer Center; University of Hawaii; Honolulu, HI USA.

Funding

Roles of the Fanconi Anemia Pathway in Bladder TumorigenesisR01CA136532 · NCI · UNIVERSITY OF MINNESOTA · PI FEI, PEIWEN · 2009 to 2013
$1.5M
NCI NIH HHS R01 CA136532NCI NIH HHS R01CA136532
6 · The paper itself

Abstract

Extremely high cancer incidence in Fanconi anemia (FA) patients has long suggested that the FA signaling pathway is a tumor suppressor pathway. Indeed, our recent findings, for the first time, indicate that the FA pathway plays a significant role in suppressing the development of non-FA human cancer. Also our studies on FA group D2 protein (FANCD2) have, among the first, documented the crosstalks between the FA and Rad6/Rad18 (HHR6) pathways upon DNA damage. In this review, we will discuss how our studies enhance the understanding of the FA tumor suppressor pathway.

Indexed as

Genes, Tumor SuppressorAnimalsDNA DamageFanconi AnemiaFanconi Anemia Complementation Group D2 ProteinHumansNeoplasmsSignal TransductionUbiquitinationFanconi Anemia Complementation Group D2 ProteinDNA damageDNA polymerase etanon-FA human tumorsRad6/Rad18 pathwaythe FA tumor suppressor pathwaytranslesion synthesis

Identifiers

PMID24025411
PMCPMC3912030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.