ArticlePlant signaling & behavior2013
Pipecolic acid enhances resistance to bacterial infection and primes salicylic acid and nicotine accumulation in tobacco.
Article in Plant signaling & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 86 citations in OpenAlex.
- Pipecolic acid modulates physiological parameters and biotic stress resilience in Mesembryanthemum crystallinum in a photosynthetic mode-dependent manner.BMC plant biology · 2026Article
- Metabolomic Profiling Identifies Key Metabolites and Defense Pathways inInternational journal of molecular sciences · 2025Article
- 3D Mass Spectrometry Imaging as a Novel Screening Method for Evaluating Biocontrol Agents.Journal of agricultural and food chemistry · 2025Article
- Chemical and Biological Characterization of the Ethyl Acetate Fraction from the Red Sea Marine SpongePharmaceuticals (Basel, Switzerland) · 2024Article
- Systemic biochemical changes in pepper (Capsicum annuum L.) against Rhizoctonia solani by kale (Brassica oleracea var. acephala L.) green manure application.BMC plant biology · 2023Article
- Chemical priming of plant defense responses to pathogen attacks.Frontiers in plant science · 2023Review
- N-hydroxypipecolic acid primes plants for enhanced microbial pattern-induced responses.Frontiers in plant science · 2023Article
- Evaluation ofHeliyon · 2023Article
- Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis.Inflammation · 2022Article
- A Novel Role of Pipecolic Acid Biosynthetic Pathway in Drought Tolerance through the Antioxidant System in Tomato.Antioxidants (Basel, Switzerland) · 2021Article
- The glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity.The Plant cell · 2021Article
- UGT76B1, a promiscuous hub of small molecule-based immune signaling, glucosylates N-hydroxypipecolic acid, and balances plant immunity.The Plant cell · 2021Article
- Multi-Omics Revealed Molecular Mechanisms Underlying Guard Cell Systemic Acquired Resistance.International journal of molecular sciences · 2020Article
- Pipecolic Acid Quantification Using Gas Chromatography-coupled Mass Spectrometry.Bio-protocol · 2020Article
- Inducible biosynthesis and immune function of the systemic acquired resistance inducer N-hydroxypipecolic acid in monocotyledonous and dicotyledonous plants.Journal of experimental botany · 2020Article
- Plant Dynamic Metabolic Response to Bacteriophage Treatment AfterFrontiers in microbiology · 2020Article
- Antiviral activity of glucosylceramides isolated from Fusarium oxysporum against Tobacco mosaic virus infection.PloS one · 2020Article
- Salicylic Acid-Producing Endophytic Bacteria Increase Nicotine Accumulation and Resistance against Wildfire Disease in Tobacco Plants.Microorganisms · 2019Article
- NbALD1 mediates resistance to turnip mosaic virus by regulating the accumulation of salicylic acid and the ethylene pathway in Nicotiana benthamiana.Molecular plant pathology · 2019Article
- A MPK3/6-WRKY33-ALD1-Pipecolic Acid Regulatory Loop Contributes to Systemic Acquired Resistance.The Plant cell · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distinct amino acid metabolic pathways constitute integral parts of the plant immune system. We have recently identified pipecolic acid (Pip), a lysine-derived non-protein amino acid, as a critical regulator of systemic acquired resistance (SAR) and basal immunity to bacterial infection in Arabidopsis thaliana. In Arabidopsis, Pip acts as an endogenous mediator of defense amplification and priming. For instance, Pip conditions plants for effective biosynthesis of the phenolic defense signal salicylic acid (SA), accumulation of the phytoalexin camalexin, and expression of defense-related genes. Here, we show that tobacco plants respond to leaf infection by the compatible bacterial pathogen Pseudomonas syringae pv tabaci (Pstb) with a significant accumulation of several amino acids, including Lys, branched-chain, aromatic, and amide group amino acids. Moreover, Pstb strongly triggers, alongside the biosynthesis of SA and increases in the defensive alkaloid nicotine, the production of the Lys catabolites Pip and α-aminoadipic acid. Exogenous application of Pip to tobacco plants provides significant protection to infection by adapted Pstb or by non-adapted, hypersensitive cell death-inducing P. syringae pv maculicola. Pip thereby primes tobacco for rapid and strong accumulation of SA and nicotine following bacterial infection. Thus, our study indicates that the role of Pip as an amplifier of immune responses is conserved between members of the rosid and asterid groups of eudicot plants and suggests a broad practical applicability for Pip as a natural enhancer of plant disease resistance.
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