ArticleJournal of natural products2013
Molecular networking as a dereplication strategy.
Article in Journal of natural products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
272 citing papers in PubMed.
- Molecular Networking-Based Annotation of Tuberostemonine Isomers Using MS/MS Spectral Similarity.Journal of separation science · 2026Article
- False Novelty in Antibacterial Natural-Product Discovery: Rediscovery, Structural Misassignment, and a Checkpoint Framework for Early Verification.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Transformation-Aware Molecular Networking for Interpretation of Untargeted LC-HRMS Data.ACS measurement science au · 2026Article
- Assessing the performance of weak and strong ion exchange solid-phase extraction and data mining tools to identify congeners and transformation products in municipal wastewaters by non-targeted analysis.Analytical and bioanalytical chemistry · 2026Article
- Metabolomics, Molecular Networking and Phytochemical Investigation ofMolecules (Basel, Switzerland) · 2026Article
- Spatial metabolomics reveals the role of penicillic acid in cheese-rind microbiome disruption by a spoilage fungus.mSystems · 2026Article
- Discovery of pyridomycin derivatives as InhA inhibitors from actinomycetes through molecular networking and an In-House tandem mass library.Natural products and bioprospecting · 2026Article
- Exploring the chemodiversity of antimicrobial minalemines from Didemnum granulatum by neutral loss graph.Scientific reports · 2026Article
- Chemodiversity ofStudies in mycology · 2025Article
- Hidden gems of Benin: Unravelling the diversity ofPersoonia · 2025Article
- Molecular Networking in Cosmetic Analysis: A Review of Non-Targeted Profiling for Safety Hazards and Bioactive Compounds.Molecules (Basel, Switzerland) · 2025Review
- Spatial Metabolomics Reveals the Role of Penicillic Acid in Cheese Rind Microbiome Disruption by a Spoilage Fungus.bioRxiv : the preprint server for biology · 2025Article
- Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products.Natural product reports · 2025Review
- Combining the Strengths of MS and NMR in Biochemometrics: A Case Study onJournal of natural products · 2025Article
- Molecular networking reveals indole diterpenoids from the marine-derived fungusMarine life science & technology · 2025Article
- Strategies for Actinobacteria Isolation, Cultivation, and Metabolite Production that Are Biologically Important.ACS omega · 2025Review
- Salamandamide Lipodipeptides Are Biosynthetic Intermediate Shunt Products of the Nonamodular Nonribosomal Peptide Assembly Lines of the Viscosin Family.Journal of natural products · 2025Article
- Comparative metabolites profiling of different solvent extracts of Asparagus species cladodes using liquid chromatography-mass spectrometry-based metabolomics and molecular networking.Phytochemical analysis : PCA · 2025Article
- Dereplication of secondary metabolites from Sophora flavescens using an LC-MS/MS-based molecular networking strategy.Scientific reports · 2025Article
- Article
212 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Funding
Abstract
A major goal in natural product discovery programs is to rapidly dereplicate known entities from complex biological extracts. We demonstrate here that molecular networking, an approach that organizes MS/MS data based on chemical similarity, is a powerful complement to traditional dereplication strategies. Successful dereplication with molecular networks requires MS/MS spectra of the natural product mixture along with MS/MS spectra of known standards, synthetic compounds, or well-characterized organisms, preferably organized into robust databases. This approach can accommodate different ionization platforms, enabling cross correlations of MS/MS data from ambient ionization, direct infusion, and LC-based methods. Molecular networking not only dereplicates known molecules from complex mixtures, it also captures related analogues, a challenge for many other dereplication strategies. To illustrate its utility as a dereplication tool, we apply mass spectrometry-based molecular networking to a diverse array of marine and terrestrial microbial samples, illustrating the dereplication of 58 molecules including analogues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.