ArticleVirology journal2013
Molecular and phylogenetic analysis of the porcine kobuvirus VP1 region using infected pigs from Sichuan Province, China.
Article in Virology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Molecular insights into astrovirus, kobuvirus and rotavirus a coinfection in pigs (Sus domesticus) from Haryana, India.Tropical animal health and production · 2026Article
- Epidemiologic and Genomic Characterizations of Porcine Kobuviruses in Diarrheic and Healthy Pigs.Animals : an open access journal from MDPI · 2023Article
- A Systematic Review: Is Porcine Kobuvirus Causing Gastrointestinal Disease in Young Pigs?Veterinary sciences · 2023Review
- Epidemiology of Astrovirus, Norovirus and Sapovirus in Greek pig farms indicates high prevalence of Mamastrovirus suggesting the potential need for systematic surveillance.Porcine health management · 2022Article
- Epidemiology and genetic characteristics of murine kobuvirus from faecal samples ofThe Journal of general virology · 2021Article
- Identification and full-genome sequencing of canine kobuvirus in canine fecal samples collected from Anhui Province, eastern China.Archives of virology · 2020Article
- Detection and molecular characterization of kobuvirus from diarrheic goats in Minnesota.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- High levels of unreported intraspecific diversity among RNA viruses in faeces of neonatal piglets with diarrhoea.BMC veterinary research · 2019Article
- First detection and genetic characterization of canine Kobuvirus in domestic dogs in Thailand.BMC veterinary research · 2019Article
- Article
- Complete Genome Sequence of a Porcine Kobuvirus Variant Strain from Jiangxi, China.Genome announcements · 2017Article
- Detection of kobuvirus RNA in Japanese domestic dogs.The Journal of veterinary medical science · 2016Article
- Large-scale screening and characterization of enteroviruses and kobuviruses infecting pigs in Vietnam.The Journal of general virology · 2016Article
- Evolution and phylogeographic dissemination of endemic porcine picornaviruses in Vietnam.Virus evolution · 2016Article
- Molecular Epidemiological Investigation of Porcine kobuvirus and Its Coinfection Rate with PEDV and SaV in Northwest China.BioMed research international · 2016Article
- Epidemiological study and variation analysis of the porcine kobuvirus 3D gene in Sichuan province, China.Virologica Sinica · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPorcine kobuvirus (PKoV) is a member of the Kobuvirus genus within the Picornaviridae family. PKoV is distributed worldwide with high prevalence in clinically healthy pigs and those with diarrhea.
methodsFecal and intestinal samples (n = 163) from pig farms in Sichuan Province, China were obtained to determine the presence of PKoV using reverse transcription polymerase chain reaction assays. Specific primers were used for the amplification of the gene encoding the PKoV VP1 protein sequence. Sequence and phylogenetic analyses were conducted to clarify evolutionary relationships with other PKoV strains.
resultsApproximately 53% (87/163) of pigs tested positive for PKoV. PKoV was widespread in asymptomatic pigs and those with diarrhea. A high prevalence of PKoV was observed in pigs younger than 4 weeks and in pigs with diarrhea. Phylogenetic analysis of 36 PKoV VP1 protein sequences showed that Sichuan PKoV strains formed four distinct clusters. Two pigs with diarrhea were found to be co-infected with multiple PKoV strains. Sequence and phylogenetic analyses revealed diversity within the same host and between different hosts. Significant recombination breakpoints were observed between the CHN/SC/31-A1 and CHN/SC/31-A3 strains in the VP1 region, which were isolated from the same sample.
conclusionPKoV was endemic in Sichuan Province regardless of whether pigs were healthy or suffering from diarrhea. Based on our statistical analyses, we suggest that PKoV was the likely causative agent of high-mortality diarrhea in China from 2010. For the first time, we provide evidence for the co-existence of multiple PKoV strains in one pig, and possible recombination events in the VP1 region. Our findings provide further insights into the molecular properties of PKoV, along with its epidemiology.
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