ReviewThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2014
Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity?
Review in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Acupuncture's Regulatory Role in Glial Cells and Their Interactions for Antidepressant Effects: A Review of Research Progress.Journal of multidisciplinary healthcare · 2026Review
- Astrocytes and Astrocyte-Derived Extracellular Conduits in Opiate-Mediated Neurological Disorders.Cells · 2025Review
- Review of cocaine-induced brain vascular and cellular function changes measuredNeurophotonics · 2025Review
- Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction.Brain sciences · 2024Review
- Astrocytes modulate cerebral blood flow and neuronal response to cocaine in prefrontal cortex.Molecular psychiatry · 2024Article
- Review
- Can pharmacotherapy improve treatment outcomes in people with co-occurring major depressive and cocaine use disorders?Expert opinion on pharmacotherapy · 2021Review
- Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia.International journal of molecular sciences · 2020Article
- Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder.Molecular neuropsychiatry · 2019Article
- Compromised Dynamic Cerebral Autoregulation in Patients With Depression.Frontiers in psychiatry · 2019Article
- Characterization of the Hippocampal Neuroimmune Response to Binge-Like Ethanol Consumption in the Drinking in the Dark Model.Neuroimmunomodulation · 2019Article
- Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Altered serum levels of glial cell line-derived neurotrophic factor in male chronic schizophrenia patients with tardive dyskinesia.International journal of methods in psychiatric research · 2018Article
- Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?Alcoholism, clinical and experimental research · 2018Review
- Immune and Neuroprotective Effects of Physical Activity on the Brain in Depression.Frontiers in neuroscience · 2018Review
- In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure.Psychopharmacology · 2017Article
- HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling.Scientific reports · 2016Article
- Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core.Biological psychiatry · 2016Article
- Reliability of 7T (1) H-MRS measured human prefrontal cortex glutamate, glutamine, and glutathione signals using an adapted echo time optimized PRESS sequence: A between- and within-sessions investigation.Journal of magnetic resonance imaging : JMRI · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesPreclinical and clinical research in neuropsychiatric disorders, particularly mood and substance use disorders, have historically focused on neurons; however, glial cells-astrocytes, microglia, and oligodendrocytes - also play key roles in these disorders.
methodsPeer-reviewed PubMed/Medline articles published through December 2012 were identified using the following keyword combinations: glia, astrocytes, oligodendrocytes/glia, microglia, substance use, substance abuse, substance dependence, alcohol, opiate, opioid, cocaine, psychostimulants, stimulants, and glutamate.
resultsDepressive and substance use disorders are highly comorbid, suggesting a common or overlapping aetiology and pathophysiology. Reduced astrocyte cell number occurs in both disorders. Altered glutamate neurotransmission and metabolism - specifically changes in the levels/activity of transporters, receptors, and synaptic proteins potentially related to synaptic physiology - appear to be salient features of both disorders. Glial cell pathology may also underlie the pathophysiology of both disorders via impaired astrocytic production of neurotrophic factors. Microglial/neuroinflammatory pathology is also evident in both depressive and substance use disorders. Finally, oligodendrocyte impairment decreases myelination and impairs expression of myelin-related genes in both substance use and depressive disorders.
conclusionsGlial-mediated glutamatergic dysfunction is a common neuropathological pathway in both substance use and depression. Therefore, glutamatergic neuromodulation is a rational drug target in this comorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.