ArticleProceedings of the National Academy of Sciences of the United States of America1990
Pvt-1 transcripts are found in normal tissues and are altered by reciprocal(6;15) translocations in mouse plasmacytomas.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Competitive endogenous RNA networks: Decoding the role of long non-coding RNAs and circular RNAs in colorectal cancer chemoresistance.Journal of cellular and molecular medicine · 2024Review
- When does hepatitis B virus meet long-stranded noncoding RNAs?Frontiers in microbiology · 2022Review
- Article
- Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin.Molecular cancer · 2020Review
- Copy number-based quantification assay for non-invasive detection of PVT1-derived transcripts.PloS one · 2019Article
- Network-Based Approaches to Explore Complex Biological Systems towards Network Medicine.Genes · 2018Review
- Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer.PloS one · 2017Article
- PVT1 Exon 9: A Potential Biomarker of Aggressive Prostate Cancer?International journal of environmental research and public health · 2015Article
- PVT1: a rising star among oncogenic long noncoding RNAs.BioMed research international · 2015Review
- Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer.OncoTargets and therapy · 2014Article
- The 8q24 gene desert: an oasis of non-coding transcriptional activity.Frontiers in genetics · 2012Article
- Article
- Genomic instability and mouse microRNAs.Toxicology mechanisms and methods · 2011Review
- A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).Nature genetics · 2010Article
- Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice.Genes, chromosomes & cancer · 2009Article
- Pvt1-encoded microRNAs in oncogenesis.Retrovirology · 2008Article
- Deregulated expression of c-Myc in a translocation-negative plasmacytoma on extrachromosomal elements that carry IgH and myc genes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.The Journal of experimental medicine · 1999Article
- Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.The Journal of experimental medicine · 1998Article
- DNA repair defects associated with chromosomal translocation breaksite regions.Molecular and cellular biology · 1994Article
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse Pvt-1 (for plasmacytoma variant translocation) region maps to a chromosome 15 breakpoint region that is frequently interrupted by "variant" reciprocal chromosome translocations, rcpt(6;15), in plasmacytomas. This region lies several hundred kilobases (kb) 3' of the mouse c-myc gene (Myc) which is deregulated in both rcpt(6;15) and rcpt(12;15) plasmacytomas. rcpt(12;15) translocations apparently activate c-myc directly by interrupting the gene itself, but the mechanism causing c-myc deregulation in tumors bearing rcpt(6;15) translocations remains unknown. The indirect activation of c-myc by Pvt-1 interruption has remained an appealing possibility, but heretofore it has not been possible to establish such a connection. Furthermore, no genes from the Pvt-1 locus have been shown to be transcribed in normal tissues or in tumors with rcpt(6;15) translocations. We report the isolation of a cDNA clone, Pvt-1-1, from mouse spleen mRNA that is specific to the Pvt-1 region. This cDNA probe detects low levels of large (ca. 14 kb) RNA transcripts in normal mouse tissues. In plasmacytomas with rcpt(6;15) translocations, the Pvt-1 transcripts are elevated in abundance and truncated in size. Both changes are apparently induced by the chromosomal translocation. Expression of 14-kb Pvt-1 RNA is elevated in B-cell tumor lines that express immunoglobulin light chain genes; thus, we postulate that these translocations are facilitated by the increased DNA accessibility of immunoglobulin kappa light chain and Pvt-1 genes when they are simultaneously expressed at certain times during B-cell ontogeny.
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