Evidence map›Paper›PMID 24024838›Full record

Trial reportThe New England journal of medicine2013

Gonadal steroids and body composition, strength, and sexual function in men.

Joel S Finkelstein, Hang Lee, Sherri-Ann M Burnett-Bowie, J Carl Pallais, Elaine W Yu, Lawrence F Borges, Brent F Jones, Christopher V Barry, Kendra E Wulczyn, Bijoy J Thomas and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The New England journal of medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00114114 (Dose-Response of Gonadal Steroids and Bone Turnover in Older Men), which is not on this map. Cited by 269 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00114114 nacompletednot on this map

Dose-Response of Gonadal Steroids and Bone Turnover in Older Men

TypeinterventionalSponsorMassachusetts General HospitalRan2004 to 2017Enrolled177ConditionsHealthy VolunteersArmsTestosterone, Goserelin acetate
3 · Its place in the literature

Who cites it

269 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effect of atorvastatin on testosterone levels.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Predicting low testosterone in aging men: a systematic review.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016
    Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Exploring the efficacy and safety of a novel standardized ashwagandha (Journal of psychopharmacology (Oxford, England) · 2023
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Effect of Testosterone on Natriuretic Peptide Levels.Journal of the American College of Cardiology · 2019
    Trial
  15. Trial
  16. AdipocytesNutrients · 2018
    Trial
  17. Trial
  18. Trial
  19. Trial
  20. Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men.The Journal of clinical endocrinology and metabolism · 2016
    Trial

209 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Joel S FinkelsteinEndocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. jfinkelstein@partners.org
Hang Lee
Sherri-Ann M Burnett-Bowie
J Carl Pallais
Elaine W Yu
Lawrence F Borges
Brent F Jones
Christopher V Barry
Kendra E Wulczyn
Bijoy J Thomas
Benjamin Z Leder

Funding

ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HOGE, ELIZABETH A · 1985 to 2008
$37.4M
Physiologic effects of androgen and estrogen deficiency in young and old menR01AG030545 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 2007 to 2011
$3.1M
EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONEK24DK002759 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1999 to 2008
$1.2M
NCRR NIH HHS M01 RR001066NCRR NIH HHS RR-1066NIA NIH HHS R01 AG030545NIDDK NIH HHS K24 DK002759NIDDK NIH HHS K24 DK02759
6 · The paper itself

Abstract

backgroundCurrent approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations.

methodsWe provided 198 healthy men 20 to 50 years of age with goserelin acetate (to suppress endogenous testosterone and estradiol) and randomly assigned them to receive a placebo gel or 1.25 g, 2.5 g, 5 g, or 10 g of testosterone gel daily for 16 weeks. Another 202 healthy men received goserelin acetate, placebo gel or testosterone gel, and anastrozole (to suppress the conversion of testosterone to estradiol). Changes in the percentage of body fat and in lean mass were the primary outcomes. Subcutaneous- and intraabdominal-fat areas, thigh-muscle area and strength, and sexual function were also assessed.

resultsThe percentage of body fat increased in groups receiving placebo or 1.25 g or 2.5 g of testosterone daily without anastrozole (mean testosterone level, 44±13 ng per deciliter, 191±78 ng per deciliter, and 337±173 ng per deciliter, respectively). Lean mass and thigh-muscle area decreased in men receiving placebo and in those receiving 1.25 g of testosterone daily without anastrozole. Leg-press strength fell only with placebo administration. In general, sexual desire declined as the testosterone dose was reduced.

conclusionsThe amount of testosterone required to maintain lean mass, fat mass, strength, and sexual function varied widely in men. Androgen deficiency accounted for decreases in lean mass, muscle size, and strength; estrogen deficiency primarily accounted for increases in body fat; and both contributed to the decline in sexual function. Our findings support changes in the approach to evaluation and management of hypogonadism in men. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT00114114.).

Indexed as

Adipose TissueAdultAromatase InhibitorsBody CompositionEstradiolGoserelinHumansLibidoMaleMiddle AgedMuscle StrengthTestosteroneYoung AdultAromatase InhibitorsEstradiolGoserelinTestosterone

Identifiers

PMID24024838
PMCPMC4142768

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.