ArticleAmerican journal of respiratory cell and molecular biology2013
Experimental human exposure to air pollutants is essential to understand adverse health effects.
Article in American journal of respiratory cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Pulmonary challenge with carbon nanoparticles induces a dose-dependent increase in circulating leukocytes in healthy males.BMC pulmonary medicine · 2017Trial
- Interaction effects of temperature and ozone on lung function and markers of systemic inflammation, coagulation, and fibrinolysis: a crossover study of healthy young volunteers.Environmental health perspectives · 2015Trial
- Who Actually Dies from Indoor Air Pollution? A Forensic Perspective.Diagnostics (Basel, Switzerland) · 2026Review
- Effects of Ozone on Sickness and Depressive-like Behavioral and Biochemical Phenotypes and Their Regulation by Serum Amyloid A in Mice.International journal of molecular sciences · 2023Article
- A comparison of alternative selection methods for reporting spirometric parameters in healthy adults.Scientific reports · 2021Article
- Air pollution aggravating COVID-19 lethality? Exploration in Asian cities using statistical models.Environment, development and sustainability · 2021Article
- Environmental Health Sciences in a Translational Research Framework: More than Benches and Bedsides.Environmental health perspectives · 2019Article
- A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework.The European respiratory journal · 2017Article
- Environmental factors in cardiovascular disease.Nature reviews. Cardiology · 2015Review
- A Review of the Effects of Major Atmospheric Pollutants on Pollen Grains, Pollen Content, and Allergenicity.TheScientificWorldJournal · 2015Review
- Controlled exposures to air pollutants and risk of cardiac arrhythmia.Environmental health perspectives · 2014Review
- Update in environmental and occupational lung diseases 2013.American journal of respiratory and critical care medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Air pollution has been found to cause significant global mortality, with 6.8 million excess deaths attributed to air pollution each year, and similarly large numbers of exacerbations of asthma, chronic obstructive pulmonary disease, and cardiovascular diseases. Epidemiological research has identified associations, and experimental human exposure has provided critical information on dose-response relationships of adverse effects caused by controlled human exposure to individual pollutants. Human exposures further enable examination of the relationship of adverse effects such as symptoms and pulmonary function changes to presumed mechanisms of disease revealed through analysis of bronchoalveolar lavage fluid obtained from the lower respiratory tract. In this Perspective, we analyze the ethics of human exposure, the importance of the information gained, and the risks of such exposure. We find that these studies appear to have been done with proper approval of institutional review boards, were done with informed consent from the participants, and have rarely been associated with serious adverse events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.