ArticleNucleic acids research1990
Nuclear pre-mRNA introns: analysis and comparison of intron sequences from Tetrahymena thermophila and other eukaryotes.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 156 citations in OpenAlex.
- Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.Molecular and cellular biology · 2013Article
- High-throughput sequence analysis of Ciona intestinalis SL trans-spliced mRNAs: alternative expression modes and gene function correlates.Genome research · 2010Article
- Eimeria tenella microneme protein EtMIC4: capture of the full-length transcribed sequence and comparison with other microneme proteins.Parasitology research · 2009Article
- Macronuclear genome structure of the ciliate Nyctotherus ovalis: single-gene chromosomes and tiny introns.BMC genomics · 2008Article
- Systematic study of sequence motifs for RNA trans splicing in Trypanosoma brucei.Molecular and cellular biology · 2005Article
- Coding properties of Oxytricha trifallax (Sterkiella histriomuscorum) macronuclear chromosomes: analysis of a pilot genome project.Chromosoma · 2004Article
- Molecular basis of the size polymorphism of the first intron of the Adh-1 gene of the mediterranean fruit fly, Ceratitis capitata.Journal of molecular evolution · 2004Article
- BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents.The Biochemical journal · 2004Article
- Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Molecular evolution of eukaryotic genomes: hemiascomycetous yeast spliceosomal introns.Nucleic acids research · 2003Article
- Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe.Molecular and cellular biology · 2000Article
- SURVEY AND SUMMARY: exon-intron organization of genes in the slime mold Physarum polycephalum.Nucleic acids research · 2000Article
- Genomic organization of three novel toxins from the scorpion Buthus martensi Karsch that are active on potassium channels.The Biochemical journal · 2000Article
- Postsynaptic alpha-neurotoxin gene of the spitting cobra, Naja naja sputatrix: structure, organization, and phylogenetic analysis.Genome research · 1999Article
- The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Relationship between "proto-splice sites" and intron phases: evidence from dicodon analysis.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Both the polypyrimidine tract and the 3' splice site function prior to the first step of splicing in fission yeast.Nucleic acids research · 1997Article
- The tRNATyr-isoacceptors and their genes in the ciliate Tetrahymena thermophila: cytoplasmic tRNATyr has a QPsiA anticodon and is coded by multiple intron-containing genes.Nucleic acids research · 1997Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have sequenced 14 introns from the ciliate Tetrahymena thermophila and include these in an analysis of the 27 intron sequences available from seven T. thermophila protein-encoding genes. Consensus 5' and 3' splice junctions were determined and found to resemble the junctions of other nuclear pre-mRNA introns. Unique features are noted and discussed. Overall the introns have a mean A + T content of 85% (21% higher than neighbouring exons) with smaller introns tending towards a higher A + T content. Approximately half of the introns are less than 100 bp. Introns from other organisms (approximately 30 of each) were also examined. The introns of Dictyostelium discoideum, Caenorhabditis elegans and Drosophila melanogaster, like those of T. thermophila, have a much higher mean A + T content than their neighbouring exons (greater than 20%). Introns from plants, Neurospora crassa and Schizosaccharomyces pombe also have a significantly higher A + T content (10%-20%). Since a high A + T content is required for intron splicing in plants (58), the elevated A + T content in the introns of these other organisms may also be functionally significant. The introns of yeast (Saccharomyces cerevisiae) and mammals (humans) appear to lack this trait and thus in some aspects may be atypical. The polypyrimidine tract, so distinctive of vertebrate introns, is not a trait of the introns in the non-vertebrate organisms examined in this study.
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