ArticleMolecular metabolism2013
Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice.
Article in Molecular metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Review
- Treatment of Hypothalamic Obesity With GLP-1 Analogs.Journal of the Endocrine Society · 2024Review
- Ghrelin mediates exercise endurance and the feeding response post-exercise.Molecular metabolism · 2018Article
- The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting.Molecular metabolism · 2017Article
- POMC Neurons: From Birth to Death.Annual review of physiology · 2017Review
- RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat.Scientific reports · 2016Article
- Effect of two GABA-ergic drugs on the cognitive functions of rapid eye movement in sleep-deprived and recovered rats.Experimental and therapeutic medicine · 2016Article
- Ghrelin.Molecular metabolism · 2015Review
- Participation of the central melanocortin system in metabolic regulation and energy homeostasis.Cellular and molecular life sciences : CMLS · 2014Review
- PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding.The Journal of clinical investigation · 2014Article
- Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Interrelationships between ghrelin, insulin and glucose homeostasis: Physiological relevance.World journal of diabetes · 2014Review
- Prolyl carboxypeptidase mRNA expression in the mouse brain.Brain research · 2014Article
- Hormonal regulation of the hypothalamic melanocortin system.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hypothalamic Prolyl carboxypeptidase (PRCP) plays a role in the regulation of energy metabolism by inactivating hypothalamic α-melanocyte stimulating hormone (α-MSH) levels and thus affecting melanocortin signaling. Alpha-MSH production is highly regulated both at transcriptional and posttranslational levels. Here we show that fasting induces a hypothalamic-specific up-regulation of Prcp mRNA and protein levels. Since fasting is characterized by elevated circulating ghrelin levels, we tested the effect of peripheral and central administration of ghrelin, and found that ghrelin increases hypothalamic Prcp mRNA expression. No changes in Prcp mRNA levels were detected in ghrelin knockout mice compared to their controls. Finally, ghrelin effect on PRCP expression was ghrelin receptor-mediated. Altogether our data show that ghrelin is a key regulator of hypothalamic PRCP expression, and up-regulation of PRCP by ghrelin may be an additional mechanism to decrease melanocortin signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.