ArticleMolecular metabolism2012
High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate.
Article in Molecular metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Perinatal Western-style diet exposure associated with altered sensory functional connectivity in infant Japanese macaques.Physiological reports · 2025Article
- Sweet Spot Regulation of Maternal Metabolic Health and Nutrition on β-Cell Mass in the Offspring.Advances in anatomy, embryology, and cell biology · 2024Review
- Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion.American journal of physiology. Endocrinology and metabolism · 2023Article
- Epigenetic modulation of cell fate during pancreas development.Trends in developmental biology · 2023Article
- Understanding the Long-Lasting Effects of Fetal Nutrient Restriction versus Exposure to an Obesogenic Diet on Islet-Cell Mass and Function.Metabolites · 2021Review
- Perinatal exposure to maternal obesity: Lasting cardiometabolic impact on offspring.Prenatal diagnosis · 2020Review
- Article
- Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work.Journal of developmental origins of health and disease · 2020Review
- Effects of pre- and postnatal protein restriction on maternal and offspring metabolism in the nonhuman primate.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Maternal Roux-en-Y gastric bypass impairs insulin action and endocrine pancreatic function in male F1 offspring.European journal of nutrition · 2020Article
- Maternal Interleukin-6 Is Associated With Macaque Offspring Amygdala Development and Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Curtailing PCOS.Pediatric research · 2020Review
- Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition.Molecular metabolism · 2019Article
- Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?Diabetes · 2018Review
- Maternal High-Fat Diet Effects on Adaptations to Metabolic Challenges in Male and Female Juvenile Nonhuman Primates.Obesity (Silver Spring, Md.) · 2018Article
- FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys.International journal of obesity (2005) · 2018Article
- Early High-Fat Diet Exposure Causes Dysregulation of the Orexin and Dopamine Neuronal Populations in Nonhuman Primates.Frontiers in endocrinology · 2018Article
- Adverse Placental Perfusion and Pregnancy Outcomes in a New Nonhuman Primate Model of Gestational Protein Restriction.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Maternal and postnatal high-fat diet consumption programs energy balance and hypothalamic melanocortin signaling in nonhuman primate offspring.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Developmental programming of the pancreatic islet byTrends in developmental biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
We investigated the impact of poor maternal nutrition and metabolic health on the development of islets of the nonhuman primate (NHP). Interestingly, fetal offspring of high fat diet (HFD) fed animals had normal total islet and β cell mass; however, there was a significant reduction in α cell mass, and decreased expression of transcription factors involved in α cell differentiation. In juvenile animals all offspring maintained on a HFD during the postweaning period demonstrated increases in total islet mass, however, the control offspring displaying increased islet number, and HFD offspring displayed increased islet size. Finally, while control offspring had increases in α and β cells, the HFD offspring had increases only in β cell number. These studies indicate that consumption of a HFD diet during pregnancy in the NHP, independent of maternal metabolic health, causes long-term abnormalities in α cell plasticity that may contribute to chronic disease susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.