Evidence map›Paper›PMID 24023948›Full record

ArticlePloS one2013

Fibromyalgia: anti-inflammatory and stress responses after acute moderate exercise.

Maria Elena Bote, Juan Jose Garcia, Maria Dolores Hinchado, Eduardo Ortega

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06138171 (Psychological Layers of Nociplastic Pain), which is not on this map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06138171 completednot on this mapstarted 2023, after this paper: background citation

Psychological Layers of Nociplastic Pain: Cluster Analysis of The Role of Personality Traits, Defence Mechanisms, Central Sensitization, and Childhood Traumatic Experiences in Patients With Chronic Migraine, Fibromyalgia, and Vulvodynia

TypeobservationalSponsorUniversity of Roma La SapienzaRan2023 to 2024Enrolled1,006ConditionsFibromyalgia, Chronic Migraine, Headache, VulvodyniaArmsPsychological self-reported measures assesment (questionnaire)
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Whole body vibration exercise training for fibromyalgia.The Cochrane database of systematic reviews · 2017
    Pooled it
  4. Aerobic exercise training for adults with fibromyalgia.The Cochrane database of systematic reviews · 2017
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
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  9. Review
  10. Article
  11. Article
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  14. Article
  15. Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
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  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria Elena BoteDepartment of Physiology, University of Extremadura, Badajoz, Spain.
Juan Jose Garcia
Maria Dolores Hinchado
Eduardo Ortega

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia (FM) is characterized in part by an elevated inflammatory status, and "modified exercise" is currently proposed as being a good therapeutic help for these patients. However, the mechanisms involved in the exercise-induced benefits are still poorly understood. The objective was to evaluate the effect of a single bout of moderate cycling (45 min at 55% VO2 max) on the inflammatory (serum IL-8; chemotaxis and O2 (-) production by neutrophils; and IL-1β, TNF-α, IL-6, IL-10, and IL-18 release by monocytes) and stress (cortisol; NA; and eHsp72) responses in women diagnosed with FM compared with an aged-matched control group of healthy women (HW). IL-8, NA, and eHsp72 were determined by ELISA. Cytokines released by monocytes were determined by Bio-Plex® system (LUMINEX). Cortisol was determined by electrochemoluminiscence, chemotaxis was evaluated in Boyden chambers and O2 (-) production by NBT reduction. In the FM patients, the exercise induced a decrease in the systemic concentration of IL-8, cortisol, NA, and eHsp72; as well as in the neutrophil's chemotaxis and O2 (-) production and in the inflammatory cytokine release by monocytes. This was contrary to the completely expected exercise-induced increase in all those biomarkers in HW. In conclusion, single sessions of moderate cycling can improve the inflammatory status in FM patients, reaching values close to the situation of aged-matched HW at their basal status. The neuroendocrine mechanism seems to be an exercise-induced decrease in the stress response of these patients.

Indexed as

Exercise TherapyCase-Control StudiesChemotaxisCytokinesFemaleFibromyalgiaHSP72 Heat-Shock ProteinsHumansHydrocortisoneInflammationMiddle AgedMonocytesNeutrophilsNorepinephrineStress, PsychologicalSuperoxidesCytokinesHSP72 Heat-Shock ProteinsHydrocortisoneNorepinephrineSuperoxides

Identifiers

PMID24023948
PMCPMC3762808

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.