ArticlePloS one2013
Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Human Wound Healing Ex Vivo Model with Focus on Molecular Markers.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Xenopus as a model system for studying pigmentation and pigmentary disorders.Pigment cell & melanoma research · 2025Review
- Evolutionary conservation of leptin effects on wound healing in vertebrates: Implications for veterinary medicine.Frontiers in endocrinology · 2022Article
- Establishment of a Robust and Simple Corneal Organ Culture Model to Monitor Wound Healing.Journal of clinical medicine · 2021Article
- Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under "pathological" conditions ex vivo.Archives of dermatological research · 2021Article
- Enzyme-Digested Peptides Derived fromMarine drugs · 2021Article
- Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens.Poultry science · 2020Article
- NestinArchives of dermatological research · 2019Article
- A short peptide potentially promotes the healing of skin wound.Bioscience reports · 2019Article
- Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo.PloS one · 2019Article
- Optical coherence tomography for assessment of epithelialization in a human ex vivo wound model.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2017Article
- The cellular and molecular mechanisms of tissue repair and regeneration as revealed by studies inRegeneration (Oxford, England) · 2016Article
- Antimicrobial peptides and wound healing: biological and therapeutic considerations.Experimental dermatology · 2016Review
- Article
- A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4.The Journal of investigative dermatology · 2014Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
There remains a critical need for new therapeutics that promote wound healing in patients suffering from chronic skin wounds. This is, in part, due to a shortage of simple, physiologically and clinically relevant test systems for investigating candidate agents. The skin of amphibians possesses a remarkable regenerative capacity, which remains insufficiently explored for clinical purposes. Combining comparative biology with a translational medicine approach, we report the development and application of a simple ex vivo frog (Xenopus tropicalis) skin organ culture system that permits exploration of the effects of amphibian skin-derived agents on re-epithelialisation in both frog and human skin. Using this amphibian model, we identify thyrotropin-releasing hormone (TRH) as a novel stimulant of epidermal regeneration. Moving to a complementary human ex vivo wounded skin assay, we demonstrate that the effects of TRH are conserved across the amphibian-mammalian divide: TRH stimulates wound closure and formation of neo-epidermis in organ-cultured human skin, accompanied by increased keratinocyte proliferation and wound healing-associated differentiation (cytokeratin 6 expression). Thus, TRH represents a novel, clinically relevant neuroendocrine wound repair promoter that deserves further exploration. These complementary frog and human skin ex vivo assays encourage a comparative biology approach in future wound healing research so as to facilitate the rapid identification and preclinical testing of novel, evolutionarily conserved, and clinically relevant wound healing promoters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.