ArticlePloS one2013
Depression-like behavioral phenotypes by social and social plus visual isolation in the adult female Macaca fascicularis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Investigation of depression-like phenotypes and their behavioral correlates in cynomolgus monkeys (Macaca fascicularis).BMC zoology · 2025Article
- Early life stress and altered social behaviors: A perspective across species.Neuroscience research · 2025Review
- Recognising depression in non-human primates: a narrative review of reported signs of depression.PeerJ · 2025Review
- Social status predicts physiological and behavioral responses to chronic stress in rhesus monkeys.iScience · 2024Article
- Patterns of depression symptoms in relation to stressors and social behaviors during the COVID-19 pandemic among older youth and emerging adults in the United States.PLOS global public health · 2024Article
- Social housing status impacts rhesus monkeys' affective responding in classic threat processing tasks.Scientific reports · 2022Article
- Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model.Translational psychiatry · 2022Article
- Mental health risk factors during the first wave of the COVID-19 pandemic.BJPsych open · 2021Article
- Combined rs-fMRI study on brain functional imaging and mechanism of RAGE-DAMPs of depression: Evidence from MDD patients to chronic stress-induced depression models in cynomolgus monkeys and mice.Clinical and translational medicine · 2021Article
- The gut microbiome modulates gut-brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression.Molecular psychiatry · 2021Article
- Recommendations for Abnormal Behaviour Ethograms in Monkey Research.Animals : an open access journal from MDPI · 2021Article
- Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys.Translational psychiatry · 2021Article
- Natural and Experimental Evidence Drives Marmosets for Research on Psychiatric Disorders Related to Stress.Frontiers in behavioral neuroscience · 2021Article
- The Faster-Onset Antidepressant Effects of Hypidone Hydrochloride (YL-0919) in Monkeys Subjected to Chronic Unpredictable Stress.Frontiers in pharmacology · 2020Article
- Metabonomics reveals peripheral and central short-chain fatty acid and amino acid dysfunction in a naturally occurring depressive model of macaques.Neuropsychiatric disease and treatment · 2019Article
- Self-injurious behaviours in rhesus macaques: Potential glial mechanisms.Journal of intellectual disability research : JIDR · 2018Article
- Two Methods of Social Separation for Paired Adolescent Male Rhesus Macaques (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route.Oncotarget · 2017Article
- Common Marmosets: A Potential Translational Animal Model of Juvenile Depression.Frontiers in psychiatry · 2017Article
- Naltrexone treatment reverses astrocyte atrophy and immune dysfunction in self-harming macaques.Brain, behavior, and immunity · 2015Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods--social isolation and social plus visual isolation--which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting.
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