ArticlePloS one2013
Multivariate modeling of proteins related to trapezius myalgia, a comparative study of female cleaners with or without pain.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- High-intensity strength training improves function of chronically painful muscles: case-control and RCT studies.BioMed research international · 2014Trial
- Comparative 3-Sample 2D-DIGE Analysis of Skeletal Muscles.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia.Scientific reports · 2020Article
- Anhedonia to Gentle Touch in Fibromyalgia: Normal Sensory Processing but Abnormal Evaluation.Brain sciences · 2020Article
- Protein Signature in Saliva of Temporomandibular Disorders Myalgia.International journal of molecular sciences · 2020Article
- Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model.BioMed research international · 2019Article
- Plasma Protein Pattern Correlates With Pain Intensity and Psychological Distress in Women With Chronic Widespread Pain.Frontiers in psychology · 2018Article
- Physical Activity as Cause and Cure of Muscular Pain: Evidence of Underlying Mechanisms.Exercise and sport sciences reviews · 2017Review
- Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma.Journal of pain research · 2017Article
- Specific proteins of the trapezius muscle correlate with pain intensity and sensitivity - an explorative multivariate proteomic study of the trapezius muscle in women with chronic widespread pain.Journal of pain research · 2016Article
- Protein alterations in women with chronic widespread pain--An explorative proteomic study of the trapezius muscle.Scientific reports · 2015Article
- Algogenic substances and metabolic status in work-related Trapezius Myalgia: a multivariate explorative study.BMC musculoskeletal disorders · 2014Article
- Comparative metabolomics of muscle interstitium fluid in human trapezius myalgia: an in vivo microdialysis study.European journal of applied physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of chronic trapezius myalgia is high in women with high exposure to awkward working positions, repetitive movements and movements with high precision demands. The mechanisms behind chronic trapezius myalgia are not fully understood. The purpose of this study was to explore the differences in protein content between healthy and myalgic trapezius muscle using proteomics. Muscle biopsies from 12 female cleaners with work-related trapezius myalgia and 12 pain free female cleaners were obtained from the descending part of the trapezius. Proteins were separated with two-dimensional differential gel electrophoresis (2D-DIGE) and selected proteins were identified with mass spectrometry. In order to discriminate the two groups, quantified proteins were fitted to a multivariate analysis: partial least square discriminate analysis. The model separated 28 unique proteins which were related to glycolysis, the tricaboxylic acid cycle, to the contractile apparatus, the cytoskeleton and to acute response proteins. The results suggest altered metabolism, a higher abundance of proteins related to inflammation in myalgic cleaners compared to healthy, and a possible alteration of the contractile apparatus. This explorative proteomic screening of proteins related to chronic pain in the trapezius muscle provides new important aspects of the pathophysiology behind chronic trapezius myalgia.
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