Evidence map›Paper›PMID 24023850›Full record

SynthesisPloS one2013

Potential role of microRNA-21 in the diagnosis of gastric cancer: a meta-analysis.

Zongyue Zeng, Jiangen Wang, Liuyang Zhao, Ping Hu, Hailong Zhang, Xi Tang, Dali He, Shifu Tang, Zhaofang Zeng

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 12 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 12 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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  7. Diagnostic Accuracy of Serum CA19-9 in Patients with Cholangiocarcinoma: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
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  8. The clinical value of ncRNAs in gastric cancer: a systematic review and meta-analyses.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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  10. The clinical utility of microRNA-21 as novel biomarker for diagnosing human cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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  11. Circulating microRNA-21 as a biomarker for the detection of various carcinomas: an updated meta-analysis based on 36 studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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  15. Diagnostic Potential ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zongyue ZengCollege of Laboratory Medicine, Key Laboratory of Laboratory Medical Diagnostics designated by Chinese Ministry of Education, Chong Qing Medical University, Chongqing, China.
Jiangen Wang
Liuyang Zhao
Ping Hu
Hailong Zhang
Xi Tang
Dali He
Shifu Tang
Zhaofang Zeng

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAccumulating evidences indicate that microRNA-21(miR-21) show significant high concentration in plasma of gastric cancer (GC) patients compared to normal individuals, suggesting that it may be a useful novel diagnostic biomarker for gastric cancer. Therefore, we aimed to assess the potential diagnostic value of miR-21 for gastric cancer in this study.

methodsLiterature database including PubMed, Embase, the Cochrane Library, Web of Science, Ovid, SciVerse, Science Direct, Scopus, BioMed Central, Biosis previews,Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang DATA were searched for publications concerning the diagnostic value of miR-21 for GC without language restriction. The quality of each study was scored with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS). Then, data were retrieved from any qualified article hits and subject to meta-analysis. Receiver operating characteristic curves (ROC) were used to check the overall test performance. Evidence of heterogeneity was evaluated using the Chi-square and I (2) test.

resultsFive studies with a total 251 GC patients and 184 control individuals were included in this meta-analysis. All of the included studies are of high quality (QUADAS score$13). The summary estimates revealed that the pooled sensitivity is 66.5% (95% confidence interval (CI): 55.0%-76.3%) and the specificity is 83.1% (95% CI: 69.4%-91.5%). In addition, the area under the summary ROC curve (AUC) is 0.80.

conclusionThe current evidence suggests that miR-21 has potential diagnostic value with a moderate sensitivity and specificity for GC. More prospective studies on the diagnostic value of miR-21 for GC are needed in the future.

Indexed as

HumansMicroRNAsStomach NeoplasmsMicroRNAsMIRN21 microRNA, human

Identifiers

PMID24023850
PMCPMC3762732
OpenAlexW1970089531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.