ArticlePloS one2013
CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Elevated Serum Soluble CD137 in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis Highlights a Shared Immunoregulatory Signature.Biomedicines · 2026Article
- Transcriptomic analysis identifies lactoferrin-induced quiescent circuits in neonatal macrophages.Frontiers in immunology · 2023Article
- Adiponectin administration alleviates DSS-induced colonic inflammation in Caco-2 cells and mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Article
- Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury.Oncotarget · 2017Article
- Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?Immune network · 2015Review
- 4-1BB Agonists: Multi-Potent Potentiators of Tumor Immunity.Frontiers in oncology · 2015Review
- CD137 signaling enhances tight junction resistance in intestinal epithelial cells.Physiological reports · 2014Article
- The role of CXCR3 in DSS-induced colitis.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCD137 and its ligand (CD137L) are potent immunoregulatory molecules that influence activation, proliferation, differentiation and cell death of leukocytes. Expression of CD137 is upregulated in the lamina propria cells of Crohn's disease patients. Here, the role of CD137 in acute Dextran-Sodium-Sulfate (DSS)-induced colitis in mice was examined.
methodsWe induced acute large bowel inflammation (colitis) via DSS administration in CD137(-/-) and wild-type (WT) mice. Colitis severity was evaluated by clinical parameters (weight loss), cytokine secretion in colon segment cultures, and scoring of histological inflammatory parameters. Additionally, populations of lamina propria mononuclear cells (LPMNC) and intraepithelial lymphocytes (IEL) were characterized by flow cytometry. In a subset of mice, resolution of intestinal inflammation was evaluated 3 and 7 days after withdrawal of DSS.
resultsWe found that both CD137(-/-) and WT mice demonstrated a similar degree of inflammation after 5 days of DSS exposure. However, the resolution of colonic inflammation was impaired in the absence of CD137. This was accompanied by a higher histological score of inflammation, and increased release of the pro-inflammatory mediators granulocyte macrophage colony-stimulating factor (GM-CSF), CXCL1, IL-17 and IFN-γ. Further, there were significantly more neutrophils among the LPMNC of CD137(-/-) mice, and reduced numbers of macrophages among the IEL.
conclusionWe conclude that CD137 plays an essential role in the resolution of acute DSS-induced intestinal inflammation in mice.
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