ArticlePloS one2013
Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- DoTropical medicine and infectious disease · 2024Article
- Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis.ACS infectious diseases · 2024Article
- Transfusion-transmittedJournal of clinical microbiology · 2023Review
- Article
- Why is Babesia not killed by artemisinin like Plasmodium?Parasites & vectors · 2023Article
- Whole genome sequence and diversity in multigene families ofFrontiers in cellular and infection microbiology · 2023Article
- Identification and phylogenetic analysis of Babesia parasites in domestic dogs in Nigeria.The Journal of veterinary medical science · 2022Article
- HarnessingVaccines · 2022Review
- Cytochrome b Drug Resistance Mutation Decreases Babesia Fitness in the Tick Stages But Not the Mammalian Erythrocytic Cycle.The Journal of infectious diseases · 2022Article
- Mitochondrial genome of Theileria uilenbergi endemic in sheep and goats in China.Parasitology research · 2021Article
- The Elusive Mitochondrial Genomes of Apicomplexa: Where Are We Now?Frontiers in microbiology · 2021Review
- Antigen Discovery, Bioinformatics and Biological Characterization of Novel Immunodominant Babesia microti Antigens.Scientific reports · 2020Article
- Development of a SNP barcode to genotype Babesia microti infections.PLoS neglected tropical diseases · 2019Article
- Comparative 3D genome organization in apicomplexan parasites.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Babesia gibsoni endemic to Wuhan, China: mitochondrial genome sequencing, annotation, and comparison with apicomplexan parasites.Parasitology research · 2019Article
- Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers.Journal of travel medicine · 2018Article
- Babesia microti: from Mice to Ticks to an Increasing Number of Highly Susceptible Humans.Journal of clinical microbiology · 2017Review
- Identification of 2-Cys Peroxiredoxin (BmTPx-2) as Antioxidant Active Molecule fromFrontiers in microbiology · 2017Article
- Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States.BMC genomics · 2016Article
- Comparative Bioinformatics Analysis of Transcription Factor Genes Indicates Conservation of Key Regulatory Domains among Babesia bovis, Babesia microti, and Theileria equi.PLoS neglected tropical diseases · 2016Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Babesia microti is the primary causative agent of human babesiosis, an emerging pathogen that causes a malaria-like illness with possible fatal outcome in immunocompromised patients. The genome sequence of the B. microti R1 strain was reported in 2012 and revealed a distinct evolutionary path for this pathogen relative to that of other apicomplexa. Lacking from the first genome assembly and initial molecular analyses was information about the terminal ends of each chromosome, and both the exact number of chromosomes in the nuclear genome and the organization of the mitochondrial genome remained ambiguous. We have now performed various molecular analyses to characterize the nuclear and mitochondrial genomes of the B. microti R1 and Gray strains and generated high-resolution Whole Genome maps. These analyses show that the genome of B. microti consists of four nuclear chromosomes and a linear mitochondrial genome present in four different structural types. Furthermore, Whole Genome mapping allowed resolution of the chromosomal ends, identification of areas of misassembly in the R1 genome, and genomic differences between the R1 and Gray strains, which occur primarily in the telomeric regions. These studies set the stage for a better understanding of the evolution and diversity of this important human pathogen.
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