ArticlePloS one2013
Validating excised rodent lungs for functional hyperpolarized xenon-129 MRI.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Preclinical MRI Using HyperpolarizedMolecules (Basel, Switzerland) · 2022Review
- A portable ventilator with integrated physiologic monitoring for hyperpolarizedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.Magnetic resonance in medicine · 2016Article
- Probe-Specific Procedure to Estimate Sensitivity and Detection Limits for 19F Magnetic Resonance Imaging.PloS one · 2016Article
- Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.Journal of the Royal Society, Interface · 2015Article
- XeNA: an automated 'open-source' (129)Xe hyperpolarizer for clinical use.Magnetic resonance imaging · 2014Article
- Animal models of ex vivo lung perfusion as a platform for transplantation research.World journal of experimental medicine · 2014Review
- Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Ex vivo rodent lung models are explored for physiological measurements of respiratory function with hyperpolarized (hp) (129)Xe MRI. It is shown that excised lung models allow for simplification of the technical challenges involved and provide valuable physiological insights that are not feasible using in vivo MRI protocols. A custom designed breathing apparatus enables MR images of gas distribution on increasing ventilation volumes of actively inhaled hp (129)Xe. Straightforward hp (129)Xe MRI protocols provide residual lung volume (RV) data and permit for spatially resolved tracking of small hp (129)Xe probe volumes during the inhalation cycle. Hp (129)Xe MRI of lung function in the excised organ demonstrates the persistence of post mortem airway responsiveness to intravenous methacholine challenges. The presented methodology enables physiology of lung function in health and disease without additional regulatory approval requirements and reduces the technical and logistical challenges with hp gas MRI experiments. The post mortem lung functional data can augment histological measurements and should be of interest for drug development studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.