ReviewMaedica2013
Paraoxonases as protective agents against N-acyl homoserine lactone - producing pathogenic microorganisms.
Review in Maedica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Paraoxonase 2 as a target for aging-related diseases.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026Review
- Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria.Indian journal of microbiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractParaoxonases are a group of enzymes with a high "substrate-promiscuity", being able to act on many structurally different compounds. To date, there is no consensus regarding the physiological substrate(s) of these enzymes. Recent data suggest that the N-acyl homoserine lactones (AHLs) produced by different Gram-negative bacteria, including the opportunistic Pseudomonas aeruginosa, could be such substrates. Due to the ability of paraoxonases to hydrolyze AHLs, they represent an alternative mechanism of protection against pathogen microorganisms, interfering with the quorum sensing systems that allow these bacteria to respond in a coordinate manner to different changes in the extracellular environment. This mini-review presents some novel aspects regarding the relationship between paraoxonases and the aforementioned compounds, highlighting the potential role of these enzymes as a component of the humoral innate defence system.
Indexed as
Identifiers
24023599PMC3749762W115876486What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.